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Is middle East pain syndrome (MEPS) a variant of fibromyalgia syndrome or a distinct disease?

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Title: Is middle East pain syndrome (MEPS) a variant of fibromyalgia syndrome or a distinct disease?
Authors: Mona H. Elhamamy, Adel A. Elbeialy, Maha S. Mohamed, Sabah E. Abdelraheem, Hala M. Elzomor
Source: BMC Rheumatology, Vol 9, Iss 1, Pp 1-9 (2025)
Publisher Information: BMC, 2025.
Publication Year: 2025
Collection: LCC:Diseases of the musculoskeletal system
Subject Terms: Fibromyalgia, FMS, Middle east pain syndrome, MEPS, Interleukin17 (IL-17), Madrid sonographic enthesitis index (MASEI), Diseases of the musculoskeletal system, RC925-935
Description: Abstract Background Fibromyalgia Syndrome (FMS) is a chronic disabling musculoskeletal condition of unknown aetiology characterized by generalized musculoskeletal pain, extreme fatigue, mood disturbance, impaired cognition, and lack of refreshing sleep. Middle East pain syndrome (MEPS) is a newly described pollution-induced syndrome of hyperparathyroidism and fibromyalgia mimicking rheumatoid arthritis, characterized by the radiological presence of spur-like excrescences in terminal phalanges. This study aimed to explore the inflammatory nature of Middle East pain and Fibromyalgia syndromes. Methods Eighty primary fibromyalgia patients were included in this study. They were divided into two groups, group [1] 1 of 40 FMS patients with low vitamin D levels and secondary hyperparathyroidism, which were diagnosed as MEPS, and group [2] of 40 primary FMS patients. They were subjected to full medical history taking, clinical examination and laboratory assessment including serum IL-17 by enzyme-linked immunosorbent assay technique, as well as assessment of Madrid Sonographic Enthesitis Index (MASEI) using musculoskeletal ultrasound and nailfold capillaroscopic pattern assessment. Plain X-ray films for hands were done on all patients. Results There was a statistically significant elevation of serum IL17 in the MEPS group (median = 58.3 ng/L) compared to the FMS group (median = 45.7 ng/L) as the p-value is
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2520-1026
Relation: https://doaj.org/toc/2520-1026
DOI: 10.1186/s41927-024-00428-0
Access URL: https://doaj.org/article/b164674716ab4c3a9941f7b43f69ded8
Accession Number: edsdoj.b164674716ab4c3a9941f7b43f69ded8
Database: Directory of Open Access Journals
Description
Abstract:Abstract Background Fibromyalgia Syndrome (FMS) is a chronic disabling musculoskeletal condition of unknown aetiology characterized by generalized musculoskeletal pain, extreme fatigue, mood disturbance, impaired cognition, and lack of refreshing sleep. Middle East pain syndrome (MEPS) is a newly described pollution-induced syndrome of hyperparathyroidism and fibromyalgia mimicking rheumatoid arthritis, characterized by the radiological presence of spur-like excrescences in terminal phalanges. This study aimed to explore the inflammatory nature of Middle East pain and Fibromyalgia syndromes. Methods Eighty primary fibromyalgia patients were included in this study. They were divided into two groups, group [1] 1 of 40 FMS patients with low vitamin D levels and secondary hyperparathyroidism, which were diagnosed as MEPS, and group [2] of 40 primary FMS patients. They were subjected to full medical history taking, clinical examination and laboratory assessment including serum IL-17 by enzyme-linked immunosorbent assay technique, as well as assessment of Madrid Sonographic Enthesitis Index (MASEI) using musculoskeletal ultrasound and nailfold capillaroscopic pattern assessment. Plain X-ray films for hands were done on all patients. Results There was a statistically significant elevation of serum IL17 in the MEPS group (median = 58.3 ng/L) compared to the FMS group (median = 45.7 ng/L) as the p-value is
ISSN:25201026
DOI:10.1186/s41927-024-00428-0