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Delayed blastulation and pregnancy outcomes in single frozen-thawed euploid blastocyst transfer

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Title: Delayed blastulation and pregnancy outcomes in single frozen-thawed euploid blastocyst transfer
Authors: Jingwen Lang, Ling Hong, Wanli Yang, Qiaoling Wang, Yunqing Zhi, Xiuxian Zhu, Yonglun Fu
Source: Frontiers in Endocrinology, Vol 16 (2025)
Publisher Information: Frontiers Media S.A., 2025.
Publication Year: 2025
Collection: LCC:Diseases of the endocrine glands. Clinical endocrinology
Subject Terms: euploid blastocyst transfer, delayed blastulation, frozen-thawed embryo transfer, embryo development speed, pregnancy outcomes, advanced maternal age, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Description: ObjectiveThis study aimed to evaluate the impact of embryo developmental speed on clinical outcomes in euploid blastocyst transfers, with a focus on maternal age and embryo morphological quality.MethodsA retrospective cohort study was conducted, including patients who underwent single blastocyst transfer following preimplantation genetic testing. Embryos were categorized based on developmental speed (day 5 vs. day 6 blastocysts) and further stratified by maternal age and embryo morphological quality. Clinical outcomes were compared between groups.ResultsDay 5 euploid blastocysts yielded significantly higher implantation (68.8% vs. 48.3%) and live birth rates (63.7% vs. 40.4%) than day 6 blastocysts. In the advanced-age group, day 5 euploid embryos demonstrated significantly higher implantation (72.5% vs. 40.5%) and live birth rates (68.8% vs. 28.6%) than day 6 embryos. Developmental speed influenced pregnancy outcomes in low-quality embryos, where day 6 blastocysts exhibited a reduced live birth rate (29.3% vs. 65.5%) than day 5 blastocysts.ConclusionOur findings indicate that day 5 euploid embryos are associated with better pregnancy outcomes compared to day 6 euploid embryos, with this trend being more pronounced in older participants and lower-quality embryo groups. However, day 6 euploid blastocyst transfer also yields acceptable implantation and pregnancy outcomes.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-2392
Relation: https://www.frontiersin.org/articles/10.3389/fendo.2025.1686274/full; https://doaj.org/toc/1664-2392
DOI: 10.3389/fendo.2025.1686274
Access URL: https://doaj.org/article/db0d9d0469b64f148ba18ca605618fec
Accession Number: edsdoj.b0d9d0469b64f148ba18ca605618fec
Database: Directory of Open Access Journals
Description
Abstract:ObjectiveThis study aimed to evaluate the impact of embryo developmental speed on clinical outcomes in euploid blastocyst transfers, with a focus on maternal age and embryo morphological quality.MethodsA retrospective cohort study was conducted, including patients who underwent single blastocyst transfer following preimplantation genetic testing. Embryos were categorized based on developmental speed (day 5 vs. day 6 blastocysts) and further stratified by maternal age and embryo morphological quality. Clinical outcomes were compared between groups.ResultsDay 5 euploid blastocysts yielded significantly higher implantation (68.8% vs. 48.3%) and live birth rates (63.7% vs. 40.4%) than day 6 blastocysts. In the advanced-age group, day 5 euploid embryos demonstrated significantly higher implantation (72.5% vs. 40.5%) and live birth rates (68.8% vs. 28.6%) than day 6 embryos. Developmental speed influenced pregnancy outcomes in low-quality embryos, where day 6 blastocysts exhibited a reduced live birth rate (29.3% vs. 65.5%) than day 5 blastocysts.ConclusionOur findings indicate that day 5 euploid embryos are associated with better pregnancy outcomes compared to day 6 euploid embryos, with this trend being more pronounced in older participants and lower-quality embryo groups. However, day 6 euploid blastocyst transfer also yields acceptable implantation and pregnancy outcomes.
ISSN:16642392
DOI:10.3389/fendo.2025.1686274