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Type 2 diabetes increases the risk of mortality and cardiovascular events in ischemic HFmrEF patients: a retrospective cohort study

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Název: Type 2 diabetes increases the risk of mortality and cardiovascular events in ischemic HFmrEF patients: a retrospective cohort study
Autoři: Zhican Liu, Hailong Hu, Jianping Zeng, Mingyan Jiang
Zdroj: Diabetology & Metabolic Syndrome, Vol 17, Iss 1, Pp 1-16 (2025)
Informace o vydavateli: BMC, 2025.
Rok vydání: 2025
Sbírka: LCC:Nutritional diseases. Deficiency diseases
Témata: Type 2 diabetes Mellitus (T2DM), Heart failure with mildly reduced ejection fraction (HFmrEF), Ischemic, All cause death, Cardiovascular events, Nutritional diseases. Deficiency diseases, RC620-627
Popis: Abstract Background Type 2 diabetes mellitus (T2DM) is known to worsen the prognosis of heart failure (HF), but its specific impact on patients with ischemic versus non-ischemic heart failure with mildly reduced ejection fraction (HFmrEF) remains unclear due to limited research and conflicting evidence. Methods We conducted a retrospective study of 1,691 HFmrEF patients at Xiangtan Central Hospital. Participants were divided into four groups: ischemic with T2DM (467 patients), ischemic without T2DM (856 patients), non-ischemic with T2DM (87 patients), and non-ischemic without T2DM (281 patients). We utilized the Cox proportional hazards model to analyze differences in all-cause mortality and cardiovascular events among the groups. Results After adjusting for multiple confounding factors using the Cox proportional hazards model, the ischemic heart disease and T2DM group had a significantly higher risk of all-cause mortality compared to the ischemic group without T2DM (HR = 1.5, 95% CI = 1.2–1.9, P = 0.001). The risk of cardiovascular events was also significantly increased (HR = 1.3, 95% CI = 1.1–1.5, P = 0.001). In non-ischemic HFmrEF patients, T2DM was not associated with a significantly increased risk of all-cause mortality (HR = 1.0, 95% CI = 0.6–1.7, P = 0.957) or cardiovascular events (HR = 1.3, 95% CI = 0.9–1.9, P = 0.113). Conclusion T2DM significantly increases the risk of all-cause mortality and cardiovascular events in ischemic HFmrEF patients, while its impact on non-ischemic HFmrEF patients is limited. These findings underscore the importance of managing T2DM in patients with ischemic HFmrEF.
Druh dokumentu: article
Popis souboru: electronic resource
Jazyk: English
ISSN: 1758-5996
Relation: https://doaj.org/toc/1758-5996
DOI: 10.1186/s13098-025-01627-6
Přístupová URL adresa: https://doaj.org/article/9bcb773a46104ea4a3724e1ebc22a251
Přístupové číslo: edsdoj.9bcb773a46104ea4a3724e1ebc22a251
Databáze: Directory of Open Access Journals
Popis
Abstrakt:Abstract Background Type 2 diabetes mellitus (T2DM) is known to worsen the prognosis of heart failure (HF), but its specific impact on patients with ischemic versus non-ischemic heart failure with mildly reduced ejection fraction (HFmrEF) remains unclear due to limited research and conflicting evidence. Methods We conducted a retrospective study of 1,691 HFmrEF patients at Xiangtan Central Hospital. Participants were divided into four groups: ischemic with T2DM (467 patients), ischemic without T2DM (856 patients), non-ischemic with T2DM (87 patients), and non-ischemic without T2DM (281 patients). We utilized the Cox proportional hazards model to analyze differences in all-cause mortality and cardiovascular events among the groups. Results After adjusting for multiple confounding factors using the Cox proportional hazards model, the ischemic heart disease and T2DM group had a significantly higher risk of all-cause mortality compared to the ischemic group without T2DM (HR = 1.5, 95% CI = 1.2–1.9, P = 0.001). The risk of cardiovascular events was also significantly increased (HR = 1.3, 95% CI = 1.1–1.5, P = 0.001). In non-ischemic HFmrEF patients, T2DM was not associated with a significantly increased risk of all-cause mortality (HR = 1.0, 95% CI = 0.6–1.7, P = 0.957) or cardiovascular events (HR = 1.3, 95% CI = 0.9–1.9, P = 0.113). Conclusion T2DM significantly increases the risk of all-cause mortality and cardiovascular events in ischemic HFmrEF patients, while its impact on non-ischemic HFmrEF patients is limited. These findings underscore the importance of managing T2DM in patients with ischemic HFmrEF.
ISSN:17585996
DOI:10.1186/s13098-025-01627-6