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A bundle to prevent postinduction hypotension in high-risk noncardiac surgery patients: the ZERO-HYPOTENSION single-arm interventional proof-of-concept study

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Název: A bundle to prevent postinduction hypotension in high-risk noncardiac surgery patients: the ZERO-HYPOTENSION single-arm interventional proof-of-concept study
Autoři: Kristen K. Thomsen, Alina Kröker, Linda Krause, Karim Kouz, Christian Zöllner, Daniel I. Sessler, Bernd Saugel, Moritz Flick
Zdroj: BJA Open, Vol 14, Iss , Pp 100392- (2025)
Informace o vydavateli: Elsevier, 2025.
Rok vydání: 2025
Sbírka: LCC:Anesthesiology
Témata: anaesthesia induction, arterial catheter, blood pressure, general anaesthesia, haemodynamic monitoring, hypotension alarm, Anesthesiology, RD78.3-87.3
Popis: Background: Postinduction hypotension is common and associated with organ injury but might be largely preventable by careful anaesthetic management. We thus aimed to quantify the severity and duration of postinduction hypotension in high-risk noncardiac surgery patients treated with a hypotension prevention bundle. Methods: In this prospective single-arm interventional proof-of-concept study, 107 high-risk noncardiac surgery patients were treated with a hypotension prevention bundle. The bundle included continuous intra-arterial blood pressure monitoring, a hypotension alarm set at a mean arterial pressure (MAP) of 75 mm Hg, careful administration of anaesthetic drugs, and continuous administration of norepinephrine when MAP decreased below 75 mm Hg. The primary endpoint, AUC65, was derived from a plot of MAP over time for the first 15 min after induction of general anaesthesia as the area of the plot under a MAP of 65 mm Hg . Results: Of 107 patients, 55 (51%) had at least one MAP reading
Druh dokumentu: article
Popis souboru: electronic resource
Jazyk: English
ISSN: 2772-6096
Relation: http://www.sciencedirect.com/science/article/pii/S2772609625000164; https://doaj.org/toc/2772-6096
DOI: 10.1016/j.bjao.2025.100392
Přístupová URL adresa: https://doaj.org/article/e8d7a214efdd40d9a9b71be3dc4533fe
Přístupové číslo: edsdoj.8d7a214efdd40d9a9b71be3dc4533fe
Databáze: Directory of Open Access Journals
Popis
Abstrakt:Background: Postinduction hypotension is common and associated with organ injury but might be largely preventable by careful anaesthetic management. We thus aimed to quantify the severity and duration of postinduction hypotension in high-risk noncardiac surgery patients treated with a hypotension prevention bundle. Methods: In this prospective single-arm interventional proof-of-concept study, 107 high-risk noncardiac surgery patients were treated with a hypotension prevention bundle. The bundle included continuous intra-arterial blood pressure monitoring, a hypotension alarm set at a mean arterial pressure (MAP) of 75 mm Hg, careful administration of anaesthetic drugs, and continuous administration of norepinephrine when MAP decreased below 75 mm Hg. The primary endpoint, AUC65, was derived from a plot of MAP over time for the first 15 min after induction of general anaesthesia as the area of the plot under a MAP of 65 mm Hg . Results: Of 107 patients, 55 (51%) had at least one MAP reading
ISSN:27726096
DOI:10.1016/j.bjao.2025.100392