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Association Between Subclinical Depression and the Severity of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia and the Mediating Effect of Sleep Quality in Elderly Chinese Men

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Názov: Association Between Subclinical Depression and the Severity of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia and the Mediating Effect of Sleep Quality in Elderly Chinese Men
Autori: Wu Y, Sheng J, Liu X, Huang Y, Zhang Y, Feng N
Zdroj: Neuropsychiatric Disease and Treatment, Vol 21, Iss Issue 1, Pp 2371-2384 (2025)
Informácie o vydavateľovi: Dove Medical Press, 2025.
Rok vydania: 2025
Zbierka: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
LCC:Neurology. Diseases of the nervous system
Predmety: Subclinical depression, Sleep quality, LUTS/BPH, Mediating effect, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Popis: Yifan Wu,1,2,* Jiayi Sheng,1,* Xinwei Liu,1,2 Yongneng Huang,1,2 Yuwei Zhang,1,3 Ninghan Feng1,2 1Department of Urology, Jiangnan University Medical Center, Wuxi, Jiangsu Province, People’s Republic of China; 2Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China; 3Medical School of Nantong University, Nantong, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ninghan Feng, Department of Urology, Jiangnan University Medical Center, 68 Zhongshan Road, Wuxi, 214002, People’s Republic of China, Email n.feng@jiangnan.edu.cn Yuwei Zhang, Medical School of Nantong University, 9 Qiangyuan Road, Nantong, 226019, People’s Republic of China, Email zhangyw0123@njmu.edu.cnBackground and Objective: Subclinical depression and lower urinary tract symptoms (LUTS) /benign prostatic hyperplasia (BPH) are both common diseases. Studies have shown that there is an association between them, and sleep disturbances may play an important role in this relationship, however, the underlying mechanisms remain unknown. This study aims to explore the potential association between subclinical depression and LUTS/BPH, and to investigate the role of sleep quality in this relationship.Methods: This is a cross-sectional study based on clinical patients. Inpatients with BPH were recruited from the urology department as the research subjects; all were aged 60 years or older. The Patient Health Questionnaire-9 (PHQ-9), the Pittsburgh Sleep Quality Index (PSQI), and the International Prostate Symptom Score (IPSS) were used to assess subclinical depression, sleep quality, and the severity of LUTS/BPH. The patients were divided into mild and moderate-to-severe groups based on IPSS scores. Logistic regression analysis was used to assess the association between subclinical depression and LUTS/BPH severity. The mediating role of sleep quality was examined through a Structural Equation Model.Results: 806 participants were included in this study, with 218 in the mild group and 588 in the moderate-to-severe group. Results showed significantly higher PHQ-9 and PSQI scores in the moderate-to-severe group compared with those in the mild group. Logistic regression analysis revealed that subclinical depression was significantly and positively correlated with increased severity of LUTS/BPH (OR:1.90, 95% CI:1.16– 3.11). Subgroup analysis indicated a stronger association between subclinical depression and LUTS/BPH severity among participants with poor sleep quality (OR: 2.95, 95% CI:1.12– 7.73). Mediation analysis showed that sleep quality partially mediated this relationship (β=0.006, P< 0.001).Conclusion: The study illustrates that subclinical depression can serve as a predictor of the severity of LUTS/BPH, with sleep partially mediating this relationship. Consequently, it is crucial to incorporate mental health assessment and intervention into the treatment plan when managing patients with LUTS/BPH.Keywords: subclinical depression, sleep quality, LUTS/BPH, mediating effect
Druh dokumentu: article
Popis súboru: electronic resource
Jazyk: English
ISSN: 1178-2021
Relation: https://www.dovepress.com/association-between-subclinical-depression-and-the-severity-of-lower-u-peer-reviewed-fulltext-article-NDT; https://doaj.org/toc/1178-2021
Prístupová URL adresa: https://doaj.org/article/88aaaaf6c6714fdbb331475f555728db
Prístupové číslo: edsdoj.88aaaaf6c6714fdbb331475f555728db
Databáza: Directory of Open Access Journals
Popis
Abstrakt:Yifan Wu,1,2,&ast; Jiayi Sheng,1,&ast; Xinwei Liu,1,2 Yongneng Huang,1,2 Yuwei Zhang,1,3 Ninghan Feng1,2 1Department of Urology, Jiangnan University Medical Center, Wuxi, Jiangsu Province, People’s Republic of China; 2Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China; 3Medical School of Nantong University, Nantong, Jiangsu Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ninghan Feng, Department of Urology, Jiangnan University Medical Center, 68 Zhongshan Road, Wuxi, 214002, People’s Republic of China, Email n.feng@jiangnan.edu.cn Yuwei Zhang, Medical School of Nantong University, 9 Qiangyuan Road, Nantong, 226019, People’s Republic of China, Email zhangyw0123@njmu.edu.cnBackground and Objective: Subclinical depression and lower urinary tract symptoms (LUTS) /benign prostatic hyperplasia (BPH) are both common diseases. Studies have shown that there is an association between them, and sleep disturbances may play an important role in this relationship, however, the underlying mechanisms remain unknown. This study aims to explore the potential association between subclinical depression and LUTS/BPH, and to investigate the role of sleep quality in this relationship.Methods: This is a cross-sectional study based on clinical patients. Inpatients with BPH were recruited from the urology department as the research subjects; all were aged 60 years or older. The Patient Health Questionnaire-9 (PHQ-9), the Pittsburgh Sleep Quality Index (PSQI), and the International Prostate Symptom Score (IPSS) were used to assess subclinical depression, sleep quality, and the severity of LUTS/BPH. The patients were divided into mild and moderate-to-severe groups based on IPSS scores. Logistic regression analysis was used to assess the association between subclinical depression and LUTS/BPH severity. The mediating role of sleep quality was examined through a Structural Equation Model.Results: 806 participants were included in this study, with 218 in the mild group and 588 in the moderate-to-severe group. Results showed significantly higher PHQ-9 and PSQI scores in the moderate-to-severe group compared with those in the mild group. Logistic regression analysis revealed that subclinical depression was significantly and positively correlated with increased severity of LUTS/BPH (OR:1.90, 95% CI:1.16– 3.11). Subgroup analysis indicated a stronger association between subclinical depression and LUTS/BPH severity among participants with poor sleep quality (OR: 2.95, 95% CI:1.12– 7.73). Mediation analysis showed that sleep quality partially mediated this relationship (β=0.006, P< 0.001).Conclusion: The study illustrates that subclinical depression can serve as a predictor of the severity of LUTS/BPH, with sleep partially mediating this relationship. Consequently, it is crucial to incorporate mental health assessment and intervention into the treatment plan when managing patients with LUTS/BPH.Keywords: subclinical depression, sleep quality, LUTS/BPH, mediating effect
ISSN:11782021