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Investigation of Individual Variability and Temporal Fluctuations in Exhaled Nitric Oxide (FeNO) Levels in Healthy Individuals

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Bibliographic Details
Title: Investigation of Individual Variability and Temporal Fluctuations in Exhaled Nitric Oxide (FeNO) Levels in Healthy Individuals
Authors: Emi Yuda, Tomoki Ando, Yukihiro Ishida, Hiroyuki Sakano, Yutaka Yoshida
Source: Advances in Respiratory Medicine, Vol 93, Iss 4, p 26 (2025)
Publisher Information: MDPI AG, 2025.
Publication Year: 2025
Collection: LCC:Diseases of the respiratory system
LCC:Medicine (General)
Subject Terms: exhaled nitric oxide (FeNO), airway inflammation, circadian rhythm, individual variability, repeated measures ANOVA, Diseases of the respiratory system, RC705-779, Medicine (General), R5-920
Description: Measurement of nitric oxide (NO) concentration in exhaled breath (FeNO) is a quantitative, non-invasive, simple, and safe method for assessing airway inflammation. It serves as a complementary tool to other methods for evaluating airway diseases. However, little is known about the typical NO levels in healthy individuals, including individual differences and the influence of measurement timing. Therefore, this study classified measurement times into four periods and statistically analyzed NO levels in healthy individuals. The mean values among groups were compared using repeated measures ANOVA on six participants. The analysis showed large individual variations in NO levels, resulting in no significant difference (p = 0.29). Notably, greater fluctuations were observed in the morning. These findings align with previous studies suggesting the influence of circadian rhythms and the redundancy of repeated measurements. This study highlights the need to consider timing and individual variability when using FeNO as a physiological marker in healthy populations.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2543-6031
Relation: https://www.mdpi.com/2543-6031/93/4/26; https://doaj.org/toc/2543-6031
DOI: 10.3390/arm93040026
Access URL: https://doaj.org/article/7bd26241dd314deca9a60df4912b9d00
Accession Number: edsdoj.7bd26241dd314deca9a60df4912b9d00
Database: Directory of Open Access Journals
Description
Abstract:Measurement of nitric oxide (NO) concentration in exhaled breath (FeNO) is a quantitative, non-invasive, simple, and safe method for assessing airway inflammation. It serves as a complementary tool to other methods for evaluating airway diseases. However, little is known about the typical NO levels in healthy individuals, including individual differences and the influence of measurement timing. Therefore, this study classified measurement times into four periods and statistically analyzed NO levels in healthy individuals. The mean values among groups were compared using repeated measures ANOVA on six participants. The analysis showed large individual variations in NO levels, resulting in no significant difference (p = 0.29). Notably, greater fluctuations were observed in the morning. These findings align with previous studies suggesting the influence of circadian rhythms and the redundancy of repeated measurements. This study highlights the need to consider timing and individual variability when using FeNO as a physiological marker in healthy populations.
ISSN:25436031
DOI:10.3390/arm93040026