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Integrated Transcriptomic and Metabolomic Insights into Flavor-Related Metabolism in Grape Berries Across Cultivars and Developmental Stages

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Názov: Integrated Transcriptomic and Metabolomic Insights into Flavor-Related Metabolism in Grape Berries Across Cultivars and Developmental Stages
Autori: Liping Huang, Linan Zhang, Min Wang, Yue Zhu, Zhili Xun, Xi Dai, Qifeng Zhao
Zdroj: Metabolites, Vol 15, Iss 10, p 648 (2025)
Informácie o vydavateľovi: MDPI AG, 2025.
Rok vydania: 2025
Zbierka: LCC:Microbiology
Predmety: grape berries, LC–MS metabolomics, transcriptome, fruit development, transcription factors, Microbiology, QR1-502
Popis: Background: Flavor quality in grape berries is shaped by complex metabolic and regulatory networks during development. Methods: In this study, we integrated transcriptomic and LC–MS-based metabolomic analyses to investigate three cultivars (‘Mei Xiangbao’, ‘Adena Rose’, and ‘Kyoho’) at two ripening stages. Results: A total of 491 differentially accumulated metabolites (DAMs) were identified, mainly lipids, organic acids, and heterocyclic compounds. Among them, 33 core metabolites, including LysoPCs, malic acid, and linalool derivatives, were closely linked to aroma, membrane remodeling, and polyphenol biosynthesis. Transcriptome integration revealed 29 transcription factors (TFs) such as AP2/ERF, MYB, and bHLH, which showed strong associations with key metabolites, suggesting their involvement in lipid remodeling and phenylpropanoid-related pathways. Conclusions: These results provide new insights into the molecular regulation of grape flavor metabolism and highlight candidate genes and metabolites for improving berry sensory quality.
Druh dokumentu: article
Popis súboru: electronic resource
Jazyk: English
ISSN: 2218-1989
Relation: https://www.mdpi.com/2218-1989/15/10/648; https://doaj.org/toc/2218-1989
DOI: 10.3390/metabo15100648
Prístupová URL adresa: https://doaj.org/article/76afb59e70484f5f987ab16d98845cfc
Prístupové číslo: edsdoj.76afb59e70484f5f987ab16d98845cfc
Databáza: Directory of Open Access Journals
Popis
Abstrakt:Background: Flavor quality in grape berries is shaped by complex metabolic and regulatory networks during development. Methods: In this study, we integrated transcriptomic and LC–MS-based metabolomic analyses to investigate three cultivars (‘Mei Xiangbao’, ‘Adena Rose’, and ‘Kyoho’) at two ripening stages. Results: A total of 491 differentially accumulated metabolites (DAMs) were identified, mainly lipids, organic acids, and heterocyclic compounds. Among them, 33 core metabolites, including LysoPCs, malic acid, and linalool derivatives, were closely linked to aroma, membrane remodeling, and polyphenol biosynthesis. Transcriptome integration revealed 29 transcription factors (TFs) such as AP2/ERF, MYB, and bHLH, which showed strong associations with key metabolites, suggesting their involvement in lipid remodeling and phenylpropanoid-related pathways. Conclusions: These results provide new insights into the molecular regulation of grape flavor metabolism and highlight candidate genes and metabolites for improving berry sensory quality.
ISSN:22181989
DOI:10.3390/metabo15100648