View in EDS

Urinary paranitrophenol levels and risk of cancer mortality: evidence from NHANES

Saved in:
Bibliographic Details
Title: Urinary paranitrophenol levels and risk of cancer mortality: evidence from NHANES
Authors: Wei Zhang, Guiyuan Liu, Wei Yuan, Qing Guo, Yan Chen, Gaohua Han
Source: BMC Cancer, Vol 25, Iss 1, Pp 1-5 (2025)
Publisher Information: BMC, 2025.
Publication Year: 2025
Collection: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms: Paranitrophenol, All-cause mortality, Cancer mortality, NHANES, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Description: Abstract Background Paranitrophenol, a metabolite of organophosphate insecticides, was associated with various adverse health outcomes. However, the association of Paranitrophenol with all-cause and cancer mortality in adults remains unclear. Methods A total of 3,362 participants (1680 male) were included from the National Health and Nutrition Examination Surveys (NHANES). Urinary Paranitrophenol was measured using ultra-high-performance LC-MS/MS. Mortality status and causes were obtained from National Death Index. Cox proportional hazards regression analysis was performed to explore the associations between Paranitrophenol and all-cause and cancer mortality, respectively. Results After a follow-up of 22.75 thousand person-years, there were 297 deaths from all causes and 69 deaths from cancer. Comparing with the lowest quartile, the highest quartile was not associated with all-cause mortality in the neither univariate model nor adjusted model. In terms of cancer mortality, the hazard ratios and 95% confidence interval of the highest quartile is 0.44 (0.21–0.93) in the univariate model, 0.40 (0.18–0.86) in the partly-adjusted model, and 0.40 (0.18–0.88) in the fully-adjusted model. Conclusion Higher urinary Paranitrophenol levels were associated with a decreased risk of cancer mortality. This association remained independent of demographics, lifestyle factors, and comorbidities.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1471-2407
Relation: https://doaj.org/toc/1471-2407
DOI: 10.1186/s12885-025-14525-x
Access URL: https://doaj.org/article/6eb8135302c044ea909bc78e73231c3f
Accession Number: edsdoj.6eb8135302c044ea909bc78e73231c3f
Database: Directory of Open Access Journals
Description
Abstract:Abstract Background Paranitrophenol, a metabolite of organophosphate insecticides, was associated with various adverse health outcomes. However, the association of Paranitrophenol with all-cause and cancer mortality in adults remains unclear. Methods A total of 3,362 participants (1680 male) were included from the National Health and Nutrition Examination Surveys (NHANES). Urinary Paranitrophenol was measured using ultra-high-performance LC-MS/MS. Mortality status and causes were obtained from National Death Index. Cox proportional hazards regression analysis was performed to explore the associations between Paranitrophenol and all-cause and cancer mortality, respectively. Results After a follow-up of 22.75 thousand person-years, there were 297 deaths from all causes and 69 deaths from cancer. Comparing with the lowest quartile, the highest quartile was not associated with all-cause mortality in the neither univariate model nor adjusted model. In terms of cancer mortality, the hazard ratios and 95% confidence interval of the highest quartile is 0.44 (0.21–0.93) in the univariate model, 0.40 (0.18–0.86) in the partly-adjusted model, and 0.40 (0.18–0.88) in the fully-adjusted model. Conclusion Higher urinary Paranitrophenol levels were associated with a decreased risk of cancer mortality. This association remained independent of demographics, lifestyle factors, and comorbidities.
ISSN:14712407
DOI:10.1186/s12885-025-14525-x