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Spatial and temporal pattern of structure–function coupling of human brain connectome with development

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Title: Spatial and temporal pattern of structure–function coupling of human brain connectome with development
Authors: Guozheng Feng, Yiwen Wang, Weijie Huang, Haojie Chen, Jian Cheng, Ni Shu
Source: eLife, Vol 13 (2024)
Publisher Information: eLife Sciences Publications Ltd, 2024.
Publication Year: 2024
Collection: LCC:Medicine
LCC:Science
LCC:Biology (General)
Subject Terms: structure–function coupling, brain connectome, development, cognitive function, gene transcriptome, Medicine, Science, Biology (General), QH301-705.5
Description: Brain structural circuitry shapes a richly patterned functional synchronization, supporting for complex cognitive and behavioural abilities. However, how coupling of structural connectome (SC) and functional connectome (FC) develops and its relationships with cognitive functions and transcriptomic architecture remain unclear. We used multimodal magnetic resonance imaging data from 439 participants aged 5.7–21.9 years to predict functional connectivity by incorporating intracortical and extracortical structural connectivity, characterizing SC–FC coupling. Our findings revealed that SC–FC coupling was strongest in the visual and somatomotor networks, consistent with evolutionary expansion, myelin content, and functional principal gradient. As development progressed, SC–FC coupling exhibited heterogeneous alterations dominated by an increase in cortical regions, broadly distributed across the somatomotor, frontoparietal, dorsal attention, and default mode networks. Moreover, we discovered that SC–FC coupling significantly predicted individual variability in general intelligence, mainly influencing frontoparietal and default mode networks. Finally, our results demonstrated that the heterogeneous development of SC–FC coupling is positively associated with genes in oligodendrocyte-related pathways and negatively associated with astrocyte-related genes. This study offers insight into the maturational principles of SC–FC coupling in typical development.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2050-084X
Relation: https://elifesciences.org/articles/93325; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.93325
Access URL: https://doaj.org/article/6b10a346f39e417f9ec3bae4c1d3cbc2
Accession Number: edsdoj.6b10a346f39e417f9ec3bae4c1d3cbc2
Database: Directory of Open Access Journals
Description
Abstract:Brain structural circuitry shapes a richly patterned functional synchronization, supporting for complex cognitive and behavioural abilities. However, how coupling of structural connectome (SC) and functional connectome (FC) develops and its relationships with cognitive functions and transcriptomic architecture remain unclear. We used multimodal magnetic resonance imaging data from 439 participants aged 5.7–21.9 years to predict functional connectivity by incorporating intracortical and extracortical structural connectivity, characterizing SC–FC coupling. Our findings revealed that SC–FC coupling was strongest in the visual and somatomotor networks, consistent with evolutionary expansion, myelin content, and functional principal gradient. As development progressed, SC–FC coupling exhibited heterogeneous alterations dominated by an increase in cortical regions, broadly distributed across the somatomotor, frontoparietal, dorsal attention, and default mode networks. Moreover, we discovered that SC–FC coupling significantly predicted individual variability in general intelligence, mainly influencing frontoparietal and default mode networks. Finally, our results demonstrated that the heterogeneous development of SC–FC coupling is positively associated with genes in oligodendrocyte-related pathways and negatively associated with astrocyte-related genes. This study offers insight into the maturational principles of SC–FC coupling in typical development.
ISSN:2050084X
DOI:10.7554/eLife.93325