Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease
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| Název: | Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease |
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| Autoři: | Yoshikazu Nakano, Shigeki Hirano, Mitsuyoshi Tamura, Yume Koizumi, Yoshihisa Kitayama, Michiko Izumi, Masahide Suzuki, Kosuke Yamagishi, Yutaro Suzuki, Shinobu Ikeda, Ayaka Arase, Tatsuya Yamamoto, Yoshitaka Yamanaka, Atsuhiko Sugiyama, Kazumoto Shibuya, Takuro Horikoshi, Takashi Uno, David Eidelberg, Satoshi Kuwabara |
| Zdroj: | Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025) |
| Informace o vydavateli: | Nature Portfolio, 2025. |
| Rok vydání: | 2025 |
| Sbírka: | LCC:Medicine LCC:Science |
| Témata: | Parkinson’s disease, Rigidity, Torque-angle measurement, Brain perfusion, Single photon emission tomography (SPECT), Network analysis, Medicine, Science |
| Popis: | Abstract Rigidity, a cardinal symptom of Parkinson’s disease (PD), remains challenging to assess objectively. A torque-angle instrument was developed to quantify muscle tone, providing two parameters: bias difference and elastic coefficient. This study aimed to investigate the association of the instrument-measured rigidity with clinical assessments and brain function. In 30 patients with PD, the muscle tone in both arms was evaluated. Ten with wearing-off phenomenon were assessed twice, off and on condition. Twentynine patients underwent brain perfusion single-photon emission computed tomography (SPECT), and expression of PD-related covariance pattern (PDRP) was computed. Bias difference and elastic coefficient showed positive correlations with physician-rated rigidity (P |
| Druh dokumentu: | article |
| Popis souboru: | electronic resource |
| Jazyk: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-025-91567-y |
| Přístupová URL adresa: | https://doaj.org/article/59da16a394b4426192914f71db4c617f |
| Přístupové číslo: | edsdoj.59da16a394b4426192914f71db4c617f |
| Databáze: | Directory of Open Access Journals |
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Nájsť tento článok vo Web of Science | Abstrakt: | Abstract Rigidity, a cardinal symptom of Parkinson’s disease (PD), remains challenging to assess objectively. A torque-angle instrument was developed to quantify muscle tone, providing two parameters: bias difference and elastic coefficient. This study aimed to investigate the association of the instrument-measured rigidity with clinical assessments and brain function. In 30 patients with PD, the muscle tone in both arms was evaluated. Ten with wearing-off phenomenon were assessed twice, off and on condition. Twentynine patients underwent brain perfusion single-photon emission computed tomography (SPECT), and expression of PD-related covariance pattern (PDRP) was computed. Bias difference and elastic coefficient showed positive correlations with physician-rated rigidity (P |
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| ISSN: | 20452322 |
| DOI: | 10.1038/s41598-025-91567-y |