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The impact of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) on the development of prediabetes in middle-aged and older Chinese adults: a national cohort study

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Název: The impact of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) on the development of prediabetes in middle-aged and older Chinese adults: a national cohort study
Autoři: Jintao Chen, Liying Yan, Qingan Fu, Miao Yu, Yue Zhou
Zdroj: Journal of Health, Population and Nutrition, Vol 44, Iss 1, Pp 1-11 (2025)
Informace o vydavateli: BMC, 2025.
Rok vydání: 2025
Sbírka: LCC:Nutritional diseases. Deficiency diseases
LCC:Public aspects of medicine
Témata: Prediabetes, NHHR, Normal fasting glucose, Middle-aged and older Chinese adults, Nutritional diseases. Deficiency diseases, RC620-627, Public aspects of medicine, RA1-1270
Popis: Abstract Background Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) has demonstrated significant clinical application potential in the evaluation of vascular-related diseases. Our objective was to explore the impact of NHHR on the progression from prediabetes to diabetes or the regression to normal fasting glucose (NFG). Method This study utilized data from the first and third waves of the China Health and Retirement Longitudinal Study, involving 2922 participants. Based on the changes in glycemic status during the follow-up period, the outcome variables were categorized into three categories: progression to diabetes, persistence in prediabetes status, or return to NFG. Multivariable logistic regression analyses, restricted cubic spline regression analyses, stratification analyses, and sensitivity analyses were used to assess the effect of NHHR on the development of prediabetes. Results In a follow-up study spanning approximately three years, we observed that 558 participants (19.1%) returned to normal blood glucose levels, while 514 participants (17.6%) progressed to diabetes. After adjusting for potential confounding factors, we found a linear negative relationship between NHHR and the reversion from prediabetes to NFG [(odds ratio (OR) 0.88, 95% confidence interval (CI) 0.80–0.98)]. Additionally, NHHR exhibited a linear positive association with the progression from prediabetes to diabetes (OR 1.28, 95% CI 1.15–1.41). Stratified analyses revealed no significant interactions between NHHR and the subgroup variables. Conclusion NHHR is significantly associated with prediabetes development in middle-aged and older adults. Lower NHHR levels increase the likelihood of prediabetes regression, whereas higher NHHR levels elevate the risk of prediabetes progression.
Druh dokumentu: article
Popis souboru: electronic resource
Jazyk: English
ISSN: 2072-1315
Relation: https://doaj.org/toc/2072-1315
DOI: 10.1186/s41043-025-01064-1
Přístupová URL adresa: https://doaj.org/article/585c8810fdbe46c8aedff47e845b8dcd
Přístupové číslo: edsdoj.585c8810fdbe46c8aedff47e845b8dcd
Databáze: Directory of Open Access Journals
Popis
Abstrakt:Abstract Background Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) has demonstrated significant clinical application potential in the evaluation of vascular-related diseases. Our objective was to explore the impact of NHHR on the progression from prediabetes to diabetes or the regression to normal fasting glucose (NFG). Method This study utilized data from the first and third waves of the China Health and Retirement Longitudinal Study, involving 2922 participants. Based on the changes in glycemic status during the follow-up period, the outcome variables were categorized into three categories: progression to diabetes, persistence in prediabetes status, or return to NFG. Multivariable logistic regression analyses, restricted cubic spline regression analyses, stratification analyses, and sensitivity analyses were used to assess the effect of NHHR on the development of prediabetes. Results In a follow-up study spanning approximately three years, we observed that 558 participants (19.1%) returned to normal blood glucose levels, while 514 participants (17.6%) progressed to diabetes. After adjusting for potential confounding factors, we found a linear negative relationship between NHHR and the reversion from prediabetes to NFG [(odds ratio (OR) 0.88, 95% confidence interval (CI) 0.80–0.98)]. Additionally, NHHR exhibited a linear positive association with the progression from prediabetes to diabetes (OR 1.28, 95% CI 1.15–1.41). Stratified analyses revealed no significant interactions between NHHR and the subgroup variables. Conclusion NHHR is significantly associated with prediabetes development in middle-aged and older adults. Lower NHHR levels increase the likelihood of prediabetes regression, whereas higher NHHR levels elevate the risk of prediabetes progression.
ISSN:20721315
DOI:10.1186/s41043-025-01064-1