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Dose-response relationship of physical activity and sedentary time with mortality in people with chronic obstructive pulmonary disease: an analysis of UK biobank accelerometer cohort

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Titel: Dose-response relationship of physical activity and sedentary time with mortality in people with chronic obstructive pulmonary disease: an analysis of UK biobank accelerometer cohort
Autoren: Weijiao Zhou, Philip T. Veliz, Junlan Pu, Wei Luo, Shaomei Shang, Janet L. Larson
Quelle: BMC Pulmonary Medicine, Vol 25, Iss 1, Pp 1-9 (2025)
Verlagsinformationen: BMC, 2025.
Publikationsjahr: 2025
Bestand: LCC:Diseases of the respiratory system
Schlagwörter: Chronic obstructive pulmonary disease, Dose-response association, Physical activity, Sedentary time, Accelerometer, Mortality, Diseases of the respiratory system, RC705-779
Beschreibung: Abstract Background The COPD guidelines recommend engaging in regular physical activity and reducing sedentary time (ST), but little is known about the optimal or minimal dose of physical activity and ST. This study aimed to quantify the prospective dose-response relationships between daily time spent in moderate to vigorous physical activity (MVPA), light physical activity (LPA), ST and mortality, and examine the theoretical consequences of replacing ST with equal time of MVPA or LPA. Methods A population-based cohort study of 1,551 individuals with COPD enrolled in the UK Biobank. MVPA, LPA, ST were measured with the wrist-worn Axivity AX3 accelerometer. All-cause mortality was obtained through the linkage to death registries. Restricted cubic splines were used to assess the dose response associations of MVPA, LPA, ST and all-cause mortality. Isotemporal substitution models were used to estimate the theoretical effect of replacing ST with MVPA or LPA. Results 54% were male, and the mean (SD) age was 66.31 (6.52) years. Over a mean (SD) follow-up of 7.44 (1.67) years, 244 (15.7%) died. We observed a significant L-shaped association between MVPA and all-cause mortality, with an optimal amount at 60 min/day (HR = 0.27, 95% CI: 0.18–0.41). For LPA, we observed a significant U-shaped association, with an optimal amount at 5.2 h/day (HR = 0.15, 95% CI: 0.10–0.25). The threshold for ST was 12.43 h/day, above which a significant increase in mortality was observed. Replacing 30 min/day of ST was associated with 34% decreased risk in mortality for MVPA (HR = 0.66, 95%CI: 0.55–0.81, P
Publikationsart: article
Dateibeschreibung: electronic resource
Sprache: English
ISSN: 1471-2466
Relation: https://doaj.org/toc/1471-2466
DOI: 10.1186/s12890-025-03969-3
Zugangs-URL: https://doaj.org/article/4c2883f3b07f41f1b50f4bdbe7819718
Dokumentencode: edsdoj.4c2883f3b07f41f1b50f4bdbe7819718
Datenbank: Directory of Open Access Journals
Beschreibung
Abstract:Abstract Background The COPD guidelines recommend engaging in regular physical activity and reducing sedentary time (ST), but little is known about the optimal or minimal dose of physical activity and ST. This study aimed to quantify the prospective dose-response relationships between daily time spent in moderate to vigorous physical activity (MVPA), light physical activity (LPA), ST and mortality, and examine the theoretical consequences of replacing ST with equal time of MVPA or LPA. Methods A population-based cohort study of 1,551 individuals with COPD enrolled in the UK Biobank. MVPA, LPA, ST were measured with the wrist-worn Axivity AX3 accelerometer. All-cause mortality was obtained through the linkage to death registries. Restricted cubic splines were used to assess the dose response associations of MVPA, LPA, ST and all-cause mortality. Isotemporal substitution models were used to estimate the theoretical effect of replacing ST with MVPA or LPA. Results 54% were male, and the mean (SD) age was 66.31 (6.52) years. Over a mean (SD) follow-up of 7.44 (1.67) years, 244 (15.7%) died. We observed a significant L-shaped association between MVPA and all-cause mortality, with an optimal amount at 60 min/day (HR = 0.27, 95% CI: 0.18–0.41). For LPA, we observed a significant U-shaped association, with an optimal amount at 5.2 h/day (HR = 0.15, 95% CI: 0.10–0.25). The threshold for ST was 12.43 h/day, above which a significant increase in mortality was observed. Replacing 30 min/day of ST was associated with 34% decreased risk in mortality for MVPA (HR = 0.66, 95%CI: 0.55–0.81, P
ISSN:14712466
DOI:10.1186/s12890-025-03969-3