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Signaling Pathways Involved in Acute Pancreatitis

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Názov: Signaling Pathways Involved in Acute Pancreatitis
Autori: Luo M, Jin T, Fang Y, Chen F, Zhu L, Bai J, Ding J
Zdroj: Journal of Inflammation Research, Vol 18, Pp 2287-2303 (2025)
Informácie o vydavateľovi: Dove Medical Press, 2025.
Rok vydania: 2025
Zbierka: LCC:Pathology
LCC:Therapeutics. Pharmacology
Predmety: acute pancreatitis, signaling pathway, calcium overload, endoplasmic reticulum stress, cell death, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Popis: Mengchen Luo,1,* Ting Jin,1,* Yi Fang,1,* Feng Chen,1 Lujian Zhu,2 Jin Bai,3 Jin Ding1 1Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 2Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 3Cancer Institute, Xuzhou Medical University, Xuzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jin Bai, Cancer Institute, Xuzhou Medical University, Xuzhou, People’s Republic of China, Email bj@xzhmu.edu.cn Jin Ding, Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China, Email jhDingJin@zju.edu.cnAbstract: Acute pancreatitis (AP) is a common digestive emergency with high morbidity and mortality. Over the past decade, significant progress has been made in understanding the mechanisms of AP, including oxidative stress, disruptions in calcium homeostasis, endoplasmic reticulum stress, inflammatory responses, and various forms of cell death. This review provides an overview of the typical signaling pathways involved and proposes the latest clinical translation prospects. These strategies are important for the early management of AP, preventing multi-organ injury, and improving the overall prognosis of the disease.Keywords: acute pancreatitis, signaling pathway, calcium overload, endoplasmic reticulum stress, cell death
Druh dokumentu: article
Popis súboru: electronic resource
Jazyk: English
ISSN: 1178-7031
Relation: https://www.dovepress.com/signaling-pathways-involved-in-acute-pancreatitis-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031
Prístupová URL adresa: https://doaj.org/article/c4bb55a7051a4b1a8761df815f51a88b
Prístupové číslo: edsdoj.4bb55a7051a4b1a8761df815f51a88b
Databáza: Directory of Open Access Journals
Popis
Abstrakt:Mengchen Luo,1,* Ting Jin,1,* Yi Fang,1,* Feng Chen,1 Lujian Zhu,2 Jin Bai,3 Jin Ding1 1Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 2Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 3Cancer Institute, Xuzhou Medical University, Xuzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jin Bai, Cancer Institute, Xuzhou Medical University, Xuzhou, People’s Republic of China, Email bj@xzhmu.edu.cn Jin Ding, Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China, Email jhDingJin@zju.edu.cnAbstract: Acute pancreatitis (AP) is a common digestive emergency with high morbidity and mortality. Over the past decade, significant progress has been made in understanding the mechanisms of AP, including oxidative stress, disruptions in calcium homeostasis, endoplasmic reticulum stress, inflammatory responses, and various forms of cell death. This review provides an overview of the typical signaling pathways involved and proposes the latest clinical translation prospects. These strategies are important for the early management of AP, preventing multi-organ injury, and improving the overall prognosis of the disease.Keywords: acute pancreatitis, signaling pathway, calcium overload, endoplasmic reticulum stress, cell death
ISSN:11787031