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Brain perfusion and blood-brain barrier permeability in systemic lupus erythematosus patients: Associations with disease activity, cognitive dysfunction, fatigue and pain

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Název: Brain perfusion and blood-brain barrier permeability in systemic lupus erythematosus patients: Associations with disease activity, cognitive dysfunction, fatigue and pain
Autoři: Tim Salomonsson, Kristoffer A. Zervides, Andreas Jönsen, Malte Knutsson, Ronnie Wirestam, Jimmy Lätt, Anders A. Bengtsson, Linda Knutsson, Pia C. Sundgren
Zdroj: NeuroImage: Reports, Vol 5, Iss 1, Pp 100232- (2025)
Informace o vydavateli: Elsevier, 2025.
Rok vydání: 2025
Sbírka: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
Témata: Systemic lupus erythematosus, Brain perfusion, Blood-brain barrier permeability, Dynamic susceptibility contrast MRI, Cognitive dysfunction, Fatigue, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Popis: High disease activity, cognitive dysfunction (CD), fatigue and pain negatively affect the quality of life in patients with systemic lupus erythematosus (SLE). However, the impact on brain perfusion and blood-brain barrier (BBB) permeability remains incompletely understood. Therefore, we utilized 3 T dynamic susceptibility contrast magnetic resonance imaging to investigate these factors in a cohort of 66 female SLE patients. Normalized leakage corrected cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and the BBB leakage parameter K2, were compared within the cohort by splitting the group into patients with and without each symptom respectively. Fourteen regions of interest were chosen, and the results were adjusted for age, disease duration, smoking and glucocorticoids. We found regional significant alterations in the different SLE subgroups compared to patients without each corresponding symptom, with patterns as follows: moderate to high disease activity (n = 17, decreased MTT, increased K2), CD in ≥1 domain (n = 36, decreased MTT, increased K2), CD in ≥2 domains (n = 20, increased CBF, CBV and K2), fatigue (n = 44, increased CBV and MTT), pain (n = 9, increased CBF and CBV, decreased MTT). Additionally, inverse correlations were found between cognitive scores and K2 in multiple areas, indicating increased BBB permeability with worse cognitive performance. To elucidate the underlying mechanisms, longitudinal studies should be conducted in a larger variation of patients, using different measurements of BBB disruption.
Druh dokumentu: article
Popis souboru: electronic resource
Jazyk: English
ISSN: 2666-9560
Relation: http://www.sciencedirect.com/science/article/pii/S2666956024000382; https://doaj.org/toc/2666-9560
DOI: 10.1016/j.ynirp.2024.100232
Přístupová URL adresa: https://doaj.org/article/3fd51185ce6c4420bb073cf40935c737
Přístupové číslo: edsdoj.3fd51185ce6c4420bb073cf40935c737
Databáze: Directory of Open Access Journals
Popis
Abstrakt:High disease activity, cognitive dysfunction (CD), fatigue and pain negatively affect the quality of life in patients with systemic lupus erythematosus (SLE). However, the impact on brain perfusion and blood-brain barrier (BBB) permeability remains incompletely understood. Therefore, we utilized 3 T dynamic susceptibility contrast magnetic resonance imaging to investigate these factors in a cohort of 66 female SLE patients. Normalized leakage corrected cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and the BBB leakage parameter K2, were compared within the cohort by splitting the group into patients with and without each symptom respectively. Fourteen regions of interest were chosen, and the results were adjusted for age, disease duration, smoking and glucocorticoids. We found regional significant alterations in the different SLE subgroups compared to patients without each corresponding symptom, with patterns as follows: moderate to high disease activity (n = 17, decreased MTT, increased K2), CD in ≥1 domain (n = 36, decreased MTT, increased K2), CD in ≥2 domains (n = 20, increased CBF, CBV and K2), fatigue (n = 44, increased CBV and MTT), pain (n = 9, increased CBF and CBV, decreased MTT). Additionally, inverse correlations were found between cognitive scores and K2 in multiple areas, indicating increased BBB permeability with worse cognitive performance. To elucidate the underlying mechanisms, longitudinal studies should be conducted in a larger variation of patients, using different measurements of BBB disruption.
ISSN:26669560
DOI:10.1016/j.ynirp.2024.100232