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Sequential surgery following Yttrium-90 resin microspheres combined with targeted therapy and immunotherapy for primary hepatocellular carcinoma: a case report

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Názov: Sequential surgery following Yttrium-90 resin microspheres combined with targeted therapy and immunotherapy for primary hepatocellular carcinoma: a case report
Autori: Fang-Yuan Hu, Jun Li, Mo-Yan Xiao, Chang-Yong Chen, Ke Ye, Ge-Wen Zhang
Zdroj: Discover Oncology, Vol 16, Iss 1, Pp 1-7 (2025)
Informácie o vydavateľovi: Springer, 2025.
Rok vydania: 2025
Zbierka: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Predmety: Carcinoma, Hepatocellular, Yttrium-90, Selective internal radiation therapy, Targeted therapy, Immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Popis: Abstract Primary hepatocellular carcinoma (HCC) is a prevalent malignancy in China, often diagnosed at intermediate to advanced stages, limiting the feasibility of curative surgical resection. Yttrium-90 selective internal radiation therapy (90Y-SIRT) has emerged as a novel treatment demonstrating potential for prolonging survival and inducing clinical remission in HCC patients. Its efficacy and safety have been progressively validated in clinical settings. This report describes a middle-aged male patient diagnosed with HCC accompanied by portal vein tumor thrombus. The treatment regimen comprised oral lenvatinib, intravenous sintilimab, and 90Y-SIRT. Successful sequential surgery was performed 7 months after 90Y-SIRT, and a 6-week follow-up showed no significant abnormalities. This case suggests that 90Y-SIRT, combined with other therapies, may be effective for patients with intermediate to advanced stage HCC.
Druh dokumentu: article
Popis súboru: electronic resource
Jazyk: English
ISSN: 2730-6011
Relation: https://doaj.org/toc/2730-6011
DOI: 10.1007/s12672-025-03014-z
Prístupová URL adresa: https://doaj.org/article/3cb92d3704fe40fe8410348c7ae8c34d
Prístupové číslo: edsdoj.3cb92d3704fe40fe8410348c7ae8c34d
Databáza: Directory of Open Access Journals
Popis
Abstrakt:Abstract Primary hepatocellular carcinoma (HCC) is a prevalent malignancy in China, often diagnosed at intermediate to advanced stages, limiting the feasibility of curative surgical resection. Yttrium-90 selective internal radiation therapy (90Y-SIRT) has emerged as a novel treatment demonstrating potential for prolonging survival and inducing clinical remission in HCC patients. Its efficacy and safety have been progressively validated in clinical settings. This report describes a middle-aged male patient diagnosed with HCC accompanied by portal vein tumor thrombus. The treatment regimen comprised oral lenvatinib, intravenous sintilimab, and 90Y-SIRT. Successful sequential surgery was performed 7 months after 90Y-SIRT, and a 6-week follow-up showed no significant abnormalities. This case suggests that 90Y-SIRT, combined with other therapies, may be effective for patients with intermediate to advanced stage HCC.
ISSN:27306011
DOI:10.1007/s12672-025-03014-z