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Prognostic Value of Systemic Inflammation Scores in Patients with Acute Coronary Syndrome Who Underwent Percutaneous Coronary Intervention: A Prospective Cohort Study

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Title: Prognostic Value of Systemic Inflammation Scores in Patients with Acute Coronary Syndrome Who Underwent Percutaneous Coronary Intervention: A Prospective Cohort Study
Authors: Wang X, Wang L, Qi Y, Liu Y, Zhang Y, Song G, Sun Q, Wei C, Liu J, Shi F, Sun L
Source: Journal of Inflammation Research, Vol 18, Iss Issue 1, Pp 15627-15643 (2025)
Publisher Information: Dove Medical Press, 2025.
Publication Year: 2025
Collection: LCC:Pathology
LCC:Therapeutics. Pharmacology
Subject Terms: Acute coronary syndrome, Prognosis, Systemic inflammation score, Percutaneous coronary intervention, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Description: Xinchen Wang,1,* Linlin Wang,1,* Yuewen Qi,2,3 Yan Liu,1 Ying Zhang,1,2,4 Ge Song,1 Qiyu Sun,3 Chen Wei,1 Jingyi Liu,1,2,4 Fei Shi,1,2,4 Lixian Sun1,2,4 1Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, People’s Republic of China; 2Hebei Key Laboratory of Panvascular Diseases, Chengde, People’s Republic of China; 3Central Laboratory, The Affiliated Hospital of Chengde Medical University, Chengde, People’s Republic of China; 4The Cardiovascular Research Institute of Chengde, Chengde, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lixian Sun, Department of Cardiology, The Affiliated Hospital of Chengde Medical University, No. 36, Nanyingzi Street, Shuangqiao District, Chengde, Hebei Province, 067000, People’s Republic of China, Tel +86 0314 227 9016, Fax +86 0314 227 4895, Email lixiansun01@126.comBackground: Acute coronary syndrome (ACS) is closely associated with inflammation status. The systemic inflammation score (SIS), which is calculated using the serum albumin level and lymphocyte-to-monocyte ratio (LMR), has emerged as a valuable biomarker for predicting the clinical outcomes of several diseases. Nonetheless, the value of SIS in predicting the long-term prognostic risk in patients with ACS undergoing percutaneous coronary intervention (PCI) remains unknown. We aimed to explore the associations of SIS with major adverse cardiovascular events (MACEs), all-cause mortality, and cardiovascular death.Methods: This prospective cohort study consecutively enrolled 1582 patients with ACS who underwent PCI at the Department of Cardiology in the Affiliated Hospital of Chengde Medical University (Chengde, China) between January 2016 and December 2018. The primary endpoint was MACEs, including all-cause mortality, rehospitalization for heart failure, revascularization, recurrence of acute myocardial infarction, and restenosis/intrastent thrombosis.Results: The Kaplan–Meier survival analysis revealed that a high SIS was correlated with MACEs and all-cause mortality and that increasing SIS was independently associated with the risks of MACEs and all-cause mortality by Cox regression. Landmark analysis provided evidence for the time window of predictive ability, which could guide clinical applications. A clear correlation between the increasing tendency of hazard ratio in patients with ACS undergoing PCI and the risks of MACEs or all-cause mortality was noted (p for trend < 0.05). The sensitivity analysis with a competing risk model showed that high SIS level was correlated with the risks of cardiac death and rehospitalization. The mediation analysis revealed that the hemoglobin level exerted a mediating effect on the relationship between SIS and MACEs.Conclusion: The SIS exhibited a strong correlation with the risks of MACEs and all-cause mortality. Notably, the SIS was particularly effective in predicting the risk of cardiac death and likelihood of rehospitalization.Keywords: acute coronary syndrome, prognosis, systemic inflammation score, percutaneous coronary intervention
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1178-7031
Relation: https://www.dovepress.com/prognostic-value-of-systemic-inflammation-scores-in-patients-with-acut-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031
Access URL: https://doaj.org/article/a3c366ea2f1d4832ab8efd5344678f97
Accession Number: edsdoj.3c366ea2f1d4832ab8efd5344678f97
Database: Directory of Open Access Journals
Description
Abstract:Xinchen Wang,1,&ast; Linlin Wang,1,&ast; Yuewen Qi,2,3 Yan Liu,1 Ying Zhang,1,2,4 Ge Song,1 Qiyu Sun,3 Chen Wei,1 Jingyi Liu,1,2,4 Fei Shi,1,2,4 Lixian Sun1,2,4 1Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, People’s Republic of China; 2Hebei Key Laboratory of Panvascular Diseases, Chengde, People’s Republic of China; 3Central Laboratory, The Affiliated Hospital of Chengde Medical University, Chengde, People’s Republic of China; 4The Cardiovascular Research Institute of Chengde, Chengde, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lixian Sun, Department of Cardiology, The Affiliated Hospital of Chengde Medical University, No. 36, Nanyingzi Street, Shuangqiao District, Chengde, Hebei Province, 067000, People’s Republic of China, Tel +86 0314 227 9016, Fax +86 0314 227 4895, Email lixiansun01@126.comBackground: Acute coronary syndrome (ACS) is closely associated with inflammation status. The systemic inflammation score (SIS), which is calculated using the serum albumin level and lymphocyte-to-monocyte ratio (LMR), has emerged as a valuable biomarker for predicting the clinical outcomes of several diseases. Nonetheless, the value of SIS in predicting the long-term prognostic risk in patients with ACS undergoing percutaneous coronary intervention (PCI) remains unknown. We aimed to explore the associations of SIS with major adverse cardiovascular events (MACEs), all-cause mortality, and cardiovascular death.Methods: This prospective cohort study consecutively enrolled 1582 patients with ACS who underwent PCI at the Department of Cardiology in the Affiliated Hospital of Chengde Medical University (Chengde, China) between January 2016 and December 2018. The primary endpoint was MACEs, including all-cause mortality, rehospitalization for heart failure, revascularization, recurrence of acute myocardial infarction, and restenosis/intrastent thrombosis.Results: The Kaplan–Meier survival analysis revealed that a high SIS was correlated with MACEs and all-cause mortality and that increasing SIS was independently associated with the risks of MACEs and all-cause mortality by Cox regression. Landmark analysis provided evidence for the time window of predictive ability, which could guide clinical applications. A clear correlation between the increasing tendency of hazard ratio in patients with ACS undergoing PCI and the risks of MACEs or all-cause mortality was noted (p for trend < 0.05). The sensitivity analysis with a competing risk model showed that high SIS level was correlated with the risks of cardiac death and rehospitalization. The mediation analysis revealed that the hemoglobin level exerted a mediating effect on the relationship between SIS and MACEs.Conclusion: The SIS exhibited a strong correlation with the risks of MACEs and all-cause mortality. Notably, the SIS was particularly effective in predicting the risk of cardiac death and likelihood of rehospitalization.Keywords: acute coronary syndrome, prognosis, systemic inflammation score, percutaneous coronary intervention
ISSN:11787031