Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches
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| Názov: | Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches |
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| Autori: | Matthew Davenport, Ha Na Choe, Hiroaki Matsunami, Erich Jarvis |
| Zdroj: | eLife, Vol 12 (2025) |
| Informácie o vydavateľovi: | eLife Sciences Publications Ltd, 2025. |
| Rok vydania: | 2025 |
| Zbierka: | LCC:Medicine LCC:Science LCC:Biology (General) |
| Predmety: | T. castanotis, vocal learning, T. guttata, sex difference, sex chromosomes, sex hormones, Medicine, Science, Biology (General), QH301-705.5 |
| Popis: | Zebra finches are sexually dimorphic vocal learners. Males learn to sing by imitating mature conspecifics, but females do not. Absence of song in females is associated with partial atrophy and apparent repression of several vocal learning brain regions during development. However, atrophy can be prevented, and vocal learning retained in females when given early pharmacological estrogen treatment. To screen for candidate drivers of this sexual dimorphism, we performed an unbiased transcriptomic analysis of song learning nuclei specializations relative to the surrounding regions from either sex, treated with vehicle or estrogen until 30 days of age when divergence between the sexes becomes anatomically apparent. Analyses of transcriptomes by RNA sequencing identified song nuclei-specialized gene expressed modules associated with sex and estrogen manipulation. Female HVC and Area X gene modules were specialized by estrogen supplementation, exhibiting a subset of the transcriptomic specializations observed in males. Female robust nucleus of the arcopallium (RA) and lateral magnocellular nucleus of the anterior nidopallium (LMAN) specialized modules were less dependent on estrogen. The estrogen-induced gene modules in females were enriched for anatomical development functions and strongly correlated to the expression of several Z sex chromosome genes. We present a hypothesis where reduced dosage and expression of these Z chromosome genes suppress the full development of the song system and thus song learning behavior, which is partially rescued by estrogen treatment. |
| Druh dokumentu: | article |
| Popis súboru: | electronic resource |
| Jazyk: | English |
| ISSN: | 2050-084X |
| Relation: | https://elifesciences.org/articles/89425; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.89425 |
| Prístupová URL adresa: | https://doaj.org/article/2caa945cc4954ec7829df38f54d7d31f |
| Prístupové číslo: | edsdoj.2caa945cc4954ec7829df38f54d7d31f |
| Databáza: | Directory of Open Access Journals |
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Nájsť tento článok vo Web of Science | Abstrakt: | Zebra finches are sexually dimorphic vocal learners. Males learn to sing by imitating mature conspecifics, but females do not. Absence of song in females is associated with partial atrophy and apparent repression of several vocal learning brain regions during development. However, atrophy can be prevented, and vocal learning retained in females when given early pharmacological estrogen treatment. To screen for candidate drivers of this sexual dimorphism, we performed an unbiased transcriptomic analysis of song learning nuclei specializations relative to the surrounding regions from either sex, treated with vehicle or estrogen until 30 days of age when divergence between the sexes becomes anatomically apparent. Analyses of transcriptomes by RNA sequencing identified song nuclei-specialized gene expressed modules associated with sex and estrogen manipulation. Female HVC and Area X gene modules were specialized by estrogen supplementation, exhibiting a subset of the transcriptomic specializations observed in males. Female robust nucleus of the arcopallium (RA) and lateral magnocellular nucleus of the anterior nidopallium (LMAN) specialized modules were less dependent on estrogen. The estrogen-induced gene modules in females were enriched for anatomical development functions and strongly correlated to the expression of several Z sex chromosome genes. We present a hypothesis where reduced dosage and expression of these Z chromosome genes suppress the full development of the song system and thus song learning behavior, which is partially rescued by estrogen treatment. |
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| ISSN: | 2050084X |
| DOI: | 10.7554/eLife.89425 |