View in EDS

Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases

Saved in:
Bibliographic Details
Title: Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases
Authors: Marie C. Sadler, Chiara Auwerx, Kaido Lepik, Eleonora Porcu, Zoltán Kutalik
Source: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Publisher Information: Nature Portfolio, 2022.
Publication Year: 2022
Collection: LCC:Science
Subject Terms: Science
Description: The mechanism by which DNA methylation might affect complex traits is not well understood. Here, the authors use Mendelian randomization to reveal a substantial role of transcript levels in mediating DNA methylation effects on complex traits and diseases.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-022-35196-3
Access URL: https://doaj.org/article/c2be3825597345b584bbf11cfe5a34d5
Accession Number: edsdoj.2be3825597345b584bbf11cfe5a34d5
Database: Directory of Open Access Journals
Description
Abstract:The mechanism by which DNA methylation might affect complex traits is not well understood. Here, the authors use Mendelian randomization to reveal a substantial role of transcript levels in mediating DNA methylation effects on complex traits and diseases.
ISSN:20411723
DOI:10.1038/s41467-022-35196-3