Advances in the design and manipulation of self-assembling peptide and protein nanostructures for biomedical applications
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| Titel: | Advances in the design and manipulation of self-assembling peptide and protein nanostructures for biomedical applications |
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| Autoren: | Xu Jianping, Gao Feng, Zhang Feng, Zhao Xinmin, Wang Liping, Guo Wenjian |
| Quelle: | Nanotechnology Reviews, Vol 14, Iss 1, Pp 3737-58 (2025) |
| Verlagsinformationen: | De Gruyter, 2025. |
| Publikationsjahr: | 2025 |
| Bestand: | LCC:Technology LCC:Chemical technology LCC:Physical and theoretical chemistry |
| Schlagwörter: | self-assembling peptide, chiral nanostructure, epitaxial growth, synthetic biology, stimuli-responsive system, Technology, Chemical technology, TP1-1185, Physical and theoretical chemistry, QD450-801 |
| Beschreibung: | Self-assembling peptides and proteins offer an unprecedented platform for constructing nanostructures with precise control over architecture and function, leveraging non-covalent interactions to achieve complex formations such as cages, layers, and hierarchical assemblies. Through design strategies like natural oligomerization, rational fusion of protein units, and structural motifs, these biomolecules form versatile nanostructures tailored for biomedical applications, including drug delivery, tissue engineering, biosensing, and catalysis. Advanced techniques, such as atomic force microscopy and epitaxial growth within confined water nanofilms, enable fine control over molecular assembly, paving the way for nanostructures with specific orientations and high spatial resolution. While challenges remain – particularly in achieving physiological stability, minimizing immunogenicity, and ensuring environmental responsiveness – progress in stimuli-responsive and bioadaptive designs holds promise for overcoming these barriers. The rational manipulation of self-assembling peptides and proteins thus stands at the forefront of advancing nanotechnology and synthetic biology, with the potential to develop adaptive, next-generation biomaterials that address critical biomedical challenges. |
| Publikationsart: | article |
| Dateibeschreibung: | electronic resource |
| Sprache: | English |
| ISSN: | 2191-9097 |
| Relation: | https://doaj.org/toc/2191-9097 |
| DOI: | 10.1515/ntrev-2025-0218 |
| Zugangs-URL: | https://doaj.org/article/16ec1d62838d4a829b0cdb8f5a183f5e |
| Dokumentencode: | edsdoj.16ec1d62838d4a829b0cdb8f5a183f5e |
| Datenbank: | Directory of Open Access Journals |
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Nájsť tento článok vo Web of Science | Abstract: | Self-assembling peptides and proteins offer an unprecedented platform for constructing nanostructures with precise control over architecture and function, leveraging non-covalent interactions to achieve complex formations such as cages, layers, and hierarchical assemblies. Through design strategies like natural oligomerization, rational fusion of protein units, and structural motifs, these biomolecules form versatile nanostructures tailored for biomedical applications, including drug delivery, tissue engineering, biosensing, and catalysis. Advanced techniques, such as atomic force microscopy and epitaxial growth within confined water nanofilms, enable fine control over molecular assembly, paving the way for nanostructures with specific orientations and high spatial resolution. While challenges remain – particularly in achieving physiological stability, minimizing immunogenicity, and ensuring environmental responsiveness – progress in stimuli-responsive and bioadaptive designs holds promise for overcoming these barriers. The rational manipulation of self-assembling peptides and proteins thus stands at the forefront of advancing nanotechnology and synthetic biology, with the potential to develop adaptive, next-generation biomaterials that address critical biomedical challenges. |
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| ISSN: | 21919097 |
| DOI: | 10.1515/ntrev-2025-0218 |