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Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo

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Titel: Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo
Autoren: Karen M. Marshall, Jonathan P. Wojciechowski, Vineetha Jayawarna, Abshar Hasan, Cécile Echalier, Øystein Øvrebø, Tao Yang, Kun Zhou, Janos M. Kanczler, Alvaro Mata, Manuel Salmeron-Sanchez, Molly M. Stevens, Richard O. C. Oreffo
Quelle: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Verlagsinformationen: Nature Portfolio, 2024.
Publikationsjahr: 2024
Bestand: LCC:Medicine
LCC:Science
Schlagwörter: Bioactive coating, Biomaterial, Bone tissue engineering, CAM assay, Animal models, Medicine, Science
Beschreibung: Abstract Bone tissue engineering aims to harness materials to develop functional bone tissue to heal ‘critical-sized’ bone defects. This study examined a robust, coated poly(caprolactone) trimethacrylate (PCL-TMA) 3D-printable scaffold designed to augment bone formation. Following optimisation of the coatings, three bioactive coatings were examined, i) elastin-like polypeptide (ELP), ii) poly(ethyl acrylate) (PEA), fibronectin (FN) and bone morphogenetic protein-2 (BMP-2) applied sequentially (PEA/FN/BMP-2) and iii) both ELP and PEA/FN/BMP-2 coatings applied concurrently. The scaffold material was robust and showed biodegradability. The coatings demonstrated a significant (p
Publikationsart: article
Dateibeschreibung: electronic resource
Sprache: English
ISSN: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-75198-3
Zugangs-URL: https://doaj.org/article/0d419b7d66ce40a3b41f8cab151ffb49
Dokumentencode: edsdoj.0d419b7d66ce40a3b41f8cab151ffb49
Datenbank: Directory of Open Access Journals
Beschreibung
Abstract:Abstract Bone tissue engineering aims to harness materials to develop functional bone tissue to heal ‘critical-sized’ bone defects. This study examined a robust, coated poly(caprolactone) trimethacrylate (PCL-TMA) 3D-printable scaffold designed to augment bone formation. Following optimisation of the coatings, three bioactive coatings were examined, i) elastin-like polypeptide (ELP), ii) poly(ethyl acrylate) (PEA), fibronectin (FN) and bone morphogenetic protein-2 (BMP-2) applied sequentially (PEA/FN/BMP-2) and iii) both ELP and PEA/FN/BMP-2 coatings applied concurrently. The scaffold material was robust and showed biodegradability. The coatings demonstrated a significant (p
ISSN:20452322
DOI:10.1038/s41598-024-75198-3