Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo
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| Název: | Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo |
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| Autoři: | Karen M. Marshall, Jonathan P. Wojciechowski, Vineetha Jayawarna, Abshar Hasan, Cécile Echalier, Øystein Øvrebø, Tao Yang, Kun Zhou, Janos M. Kanczler, Alvaro Mata, Manuel Salmeron-Sanchez, Molly M. Stevens, Richard O. C. Oreffo |
| Zdroj: | Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024) |
| Informace o vydavateli: | Nature Portfolio, 2024. |
| Rok vydání: | 2024 |
| Sbírka: | LCC:Medicine LCC:Science |
| Témata: | Bioactive coating, Biomaterial, Bone tissue engineering, CAM assay, Animal models, Medicine, Science |
| Popis: | Abstract Bone tissue engineering aims to harness materials to develop functional bone tissue to heal ‘critical-sized’ bone defects. This study examined a robust, coated poly(caprolactone) trimethacrylate (PCL-TMA) 3D-printable scaffold designed to augment bone formation. Following optimisation of the coatings, three bioactive coatings were examined, i) elastin-like polypeptide (ELP), ii) poly(ethyl acrylate) (PEA), fibronectin (FN) and bone morphogenetic protein-2 (BMP-2) applied sequentially (PEA/FN/BMP-2) and iii) both ELP and PEA/FN/BMP-2 coatings applied concurrently. The scaffold material was robust and showed biodegradability. The coatings demonstrated a significant (p |
| Druh dokumentu: | article |
| Popis souboru: | electronic resource |
| Jazyk: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-75198-3 |
| Přístupová URL adresa: | https://doaj.org/article/0d419b7d66ce40a3b41f8cab151ffb49 |
| Přístupové číslo: | edsdoj.0d419b7d66ce40a3b41f8cab151ffb49 |
| Databáze: | Directory of Open Access Journals |
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Nájsť tento článok vo Web of Science | Abstrakt: | Abstract Bone tissue engineering aims to harness materials to develop functional bone tissue to heal ‘critical-sized’ bone defects. This study examined a robust, coated poly(caprolactone) trimethacrylate (PCL-TMA) 3D-printable scaffold designed to augment bone formation. Following optimisation of the coatings, three bioactive coatings were examined, i) elastin-like polypeptide (ELP), ii) poly(ethyl acrylate) (PEA), fibronectin (FN) and bone morphogenetic protein-2 (BMP-2) applied sequentially (PEA/FN/BMP-2) and iii) both ELP and PEA/FN/BMP-2 coatings applied concurrently. The scaffold material was robust and showed biodegradability. The coatings demonstrated a significant (p |
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| ISSN: | 20452322 |
| DOI: | 10.1038/s41598-024-75198-3 |