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Association of Chronotype with Hypertension and Metabolic Parameters in Middle-Aged and Older Adults: A Cross-Sectional Study

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Název: Association of Chronotype with Hypertension and Metabolic Parameters in Middle-Aged and Older Adults: A Cross-Sectional Study
Autoři: Hu MJ, Hu WW, Yao B, Dong XM, Wang XL, Su D, Song GQ, Zhang YL
Zdroj: Nature and Science of Sleep, Vol 17, Iss Issue 1, Pp 1985-1995 (2025)
Informace o vydavateli: Dove Medical Press, 2025.
Rok vydání: 2025
Sbírka: LCC:Psychiatry
LCC:Neurophysiology and neuropsychology
Témata: Sleep, Chronotype, Metabolic parameters, Hypertension, Risk factors, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Popis: Ming-Jun Hu,1,* Wen-Wen Hu,2,* Bei Yao,1 Xiao-Min Dong,1 Xue-Li Wang,1 Dan Su,1 Gui-Qi Song,2,3 Yong-Liang Zhang1 1Department of Health Management Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China; 2School of Nursing, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 3Department of Education, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gui-Qi Song, School of Nursing, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China, Email songguiqi66@sina.com Yong-Liang Zhang, Department of Health Management Center, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China, Tel +86 0551 62284719, Email zyl2020@ustc.edu.cnPurpose: Chronotype can be used to describe individual’s circadian preference in behavioral and circadian rhythm, representing the preferences for earlier or later sleep times. This study aimed to investigate the association of chronotype with hypertension and metabolic parameters in middle-aged and older adults.Patients and Methods: A total of 945 participants were recruited from December 2023 to December 2024 at First Affiliated Hospital of University of Science and Technology of China. Chronotype was determined using the full Morningness-Eveningness Questionnaire, with higher scores indicating preference for morning chronotype. Chronotype was dichotomized at the median score in current cohort, classifying 447 participants as morning chronotypes and 498 as evening chronotypes. Anthropometric measurements and biochemical analyses were also conducted. Multivariable logistic, linear regression, and restricted cubic spline (RCS) analyses were employed to evaluate association between chronotype, metabolic parameters, and hypertension.Results: After adjustment for covariates, evening chronotype was significantly associated with hypertension risk (OR = 1.60, 95% CI: 1.17− 2.17), compared with morning chronotype. The RCS analysis suggested a significant nonlinearity association between chronotype score and hypertension (P for nonlinear = 0.047). Furthermore, higher chronotype score was significantly associated with decreased levels of total cholesterol [TC, β (95% CI): − 0.12 (− 0.19, − 0.04)], low-density lipoprotein-cholesterol [LDL-C, β (95% CI): − 0.21 (− 0.33, − 0.08)] and serum uric acid [SUA, β (95% CI): − 0.09 (− 0.18, − 0.01)], but with increased levels of aspartate aminotransferase [AST, β (95% CI): 0.16 (0.05, 0.27)]. In discrimination model, chronotype was associated with hypertension independently of TC, SUA, alanine transaminase, and alkaline phosphatase, with model’s AUC of 0.779 (95% CI: 0.749– 0.808).Conclusion: In middle-aged and older adults, preference for morning chronotype was associated with decreased levels of TC, LDL-C, and SUA, but with increased levels of AST. Moreover, evening chronotype was significantly independently associated with increased risk of hypertension.Keywords: sleep, chronotype, metabolic parameters, hypertension, risk factors
Druh dokumentu: article
Popis souboru: electronic resource
Jazyk: English
ISSN: 1179-1608
Relation: https://www.dovepress.com/association-of-chronotype-with-hypertension-and-metabolic-parameters-i-peer-reviewed-fulltext-article-NSS; https://doaj.org/toc/1179-1608
Přístupová URL adresa: https://doaj.org/article/07a8c50d2bfd42c9bb790fb4fe2da663
Přístupové číslo: edsdoj.07a8c50d2bfd42c9bb790fb4fe2da663
Databáze: Directory of Open Access Journals
Popis
Abstrakt:Ming-Jun Hu,1,* Wen-Wen Hu,2,* Bei Yao,1 Xiao-Min Dong,1 Xue-Li Wang,1 Dan Su,1 Gui-Qi Song,2,3 Yong-Liang Zhang1 1Department of Health Management Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China; 2School of Nursing, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 3Department of Education, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gui-Qi Song, School of Nursing, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China, Email songguiqi66@sina.com Yong-Liang Zhang, Department of Health Management Center, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China, Tel +86 0551 62284719, Email zyl2020@ustc.edu.cnPurpose: Chronotype can be used to describe individual’s circadian preference in behavioral and circadian rhythm, representing the preferences for earlier or later sleep times. This study aimed to investigate the association of chronotype with hypertension and metabolic parameters in middle-aged and older adults.Patients and Methods: A total of 945 participants were recruited from December 2023 to December 2024 at First Affiliated Hospital of University of Science and Technology of China. Chronotype was determined using the full Morningness-Eveningness Questionnaire, with higher scores indicating preference for morning chronotype. Chronotype was dichotomized at the median score in current cohort, classifying 447 participants as morning chronotypes and 498 as evening chronotypes. Anthropometric measurements and biochemical analyses were also conducted. Multivariable logistic, linear regression, and restricted cubic spline (RCS) analyses were employed to evaluate association between chronotype, metabolic parameters, and hypertension.Results: After adjustment for covariates, evening chronotype was significantly associated with hypertension risk (OR = 1.60, 95% CI: 1.17− 2.17), compared with morning chronotype. The RCS analysis suggested a significant nonlinearity association between chronotype score and hypertension (P for nonlinear = 0.047). Furthermore, higher chronotype score was significantly associated with decreased levels of total cholesterol [TC, β (95% CI): − 0.12 (− 0.19, − 0.04)], low-density lipoprotein-cholesterol [LDL-C, β (95% CI): − 0.21 (− 0.33, − 0.08)] and serum uric acid [SUA, β (95% CI): − 0.09 (− 0.18, − 0.01)], but with increased levels of aspartate aminotransferase [AST, β (95% CI): 0.16 (0.05, 0.27)]. In discrimination model, chronotype was associated with hypertension independently of TC, SUA, alanine transaminase, and alkaline phosphatase, with model’s AUC of 0.779 (95% CI: 0.749– 0.808).Conclusion: In middle-aged and older adults, preference for morning chronotype was associated with decreased levels of TC, LDL-C, and SUA, but with increased levels of AST. Moreover, evening chronotype was significantly independently associated with increased risk of hypertension.Keywords: sleep, chronotype, metabolic parameters, hypertension, risk factors
ISSN:11791608