Maternal prediabetes as a risk factor of preeclampsia and placental dysfunction in pregnant female Sprague-Dawley rats
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| Název: | Maternal prediabetes as a risk factor of preeclampsia and placental dysfunction in pregnant female Sprague-Dawley rats |
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| Autoři: | Aneliswe Siboto, Asiphaphola Ludidi, Ntethelelo Sibiya, Andile Khathi, Phikelelani Ngubane |
| Zdroj: | Journal of Obstetrics and Gynaecology, Vol 44, Iss 1 (2024) |
| Informace o vydavateli: | Taylor & Francis Group, 2024. |
| Rok vydání: | 2024 |
| Sbírka: | LCC:Gynecology and obstetrics |
| Témata: | Maternal prediabetes, intermediate hyperglycaemia, placental dysfunction, vasculogenesis and angiogenesis, Gynecology and obstetrics, RG1-991 |
| Popis: | Background Prediabetes (PD) is associated with intermediate hyperglycaemia, dyslipidaemia, reduced nitric oxide (NO) bioavailability and moderate hypertension. All these factors are risk factor for preeclampsia (PE). However, the effects of the PD on placental function have not been shown. Accordingly, this study sought to investigate a possible link between maternal PD and the risk of developing PE.Methods Pregnant female Sprague-Dawley rats (N = 18) were divided into normal, preeclamptic and prediabetic groups (n = 6 in each group) to study the effects of maternal PD on placenta function over the period of 19 days. Blood glucose and blood pressure were measured on gestational day (GND) 0, 9 and 18. Placental vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) mRNA expression were measured terminally. Data were analysed using ANOVA followed by the Tukey–Kramer post hoc test. Values of p |
| Druh dokumentu: | article |
| Popis souboru: | electronic resource |
| Jazyk: | English |
| ISSN: | 1364-6893 0144-3615 |
| Relation: | https://doaj.org/toc/0144-3615; https://doaj.org/toc/1364-6893 |
| DOI: | 10.1080/01443615.2024.2379498 |
| Přístupová URL adresa: | https://doaj.org/article/06d1d2d9dfe444ea882ce0995006f6e4 |
| Přístupové číslo: | edsdoj.06d1d2d9dfe444ea882ce0995006f6e4 |
| Databáze: | Directory of Open Access Journals |
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Nájsť tento článok vo Web of Science | Abstrakt: | Background Prediabetes (PD) is associated with intermediate hyperglycaemia, dyslipidaemia, reduced nitric oxide (NO) bioavailability and moderate hypertension. All these factors are risk factor for preeclampsia (PE). However, the effects of the PD on placental function have not been shown. Accordingly, this study sought to investigate a possible link between maternal PD and the risk of developing PE.Methods Pregnant female Sprague-Dawley rats (N = 18) were divided into normal, preeclamptic and prediabetic groups (n = 6 in each group) to study the effects of maternal PD on placenta function over the period of 19 days. Blood glucose and blood pressure were measured on gestational day (GND) 0, 9 and 18. Placental vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) mRNA expression were measured terminally. Data were analysed using ANOVA followed by the Tukey–Kramer post hoc test. Values of p |
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| ISSN: | 13646893 01443615 |
| DOI: | 10.1080/01443615.2024.2379498 |