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A Case Report of Refractory Mycobacterium wolinskyi Knee Infection in a Metabolic Syndrome Patient: mNGS Diagnosis and Pharmacist-Guided Therapy

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Názov: A Case Report of Refractory Mycobacterium wolinskyi Knee Infection in a Metabolic Syndrome Patient: mNGS Diagnosis and Pharmacist-Guided Therapy
Autori: Shao M, Ni L, Jiang L, Hou J, Xu S, Lin Y, Xie X
Zdroj: Infection and Drug Resistance, Vol 18, Iss Issue 1, Pp 4427-4434 (2025)
Informácie o vydavateľovi: Dove Medical Press, 2025.
Rok vydania: 2025
Zbierka: LCC:Infectious and parasitic diseases
Predmety: Mycobacterium wolinskyi, surgical site infection, metabolic syndrome, mNGS, Infectious and parasitic diseases, RC109-216
Popis: Min Shao,1,* Lijia Ni,2,3,* Liang Jiang,4 Jingyi Hou,4 Sicheng Xu,4 Yin Lin,5 Xiaoying Xie6 1Department of Pharmacy, Liwan Central Hospital of Guangzhou, Guangzhou, 510000, People’s Republic of China; 2Department of Clinical Laboratory, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 3Institution of Antibiotic, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 4Department of Orthopedic Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 5Department of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 6Department of Clinical Laboratory, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518106, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoying Xie, Email xiexy5@mail.sysu.edu.cn Yin Lin, Email linyin@mail.sysu.edu.cnAbstract: Mycobacterium wolinskyi (M. wolinskyi), which is a rare rapidly growing mycobacterium (RGM), and the infections it causes are predominantly linked to surgery or invasive procedures. We detailed a case of refractory surgical site infection (SSI) caused by M. wolinskyi. The causative pathogen was identified by metagenomic next-generation sequencing (mNGS) analysis, 16S rRNA and rpoB gene sequencing. What renders this case particularly remarkable is the complexity introduced by a series of antibiotic-induced adverse effects, which seem to be deeply intertwined with the patient’s underlying metabolic syndrome. With the meticulous pharmaceutical guidance provided by the clinical pharmacist, the patient experienced a substantial improvement in his knee joint infection.Keywords: Mycobacterium wolinskyi, surgical site infection, metabolic syndrome, mNGS
Druh dokumentu: article
Popis súboru: electronic resource
Jazyk: English
ISSN: 1178-6973
Relation: https://www.dovepress.com/a-case-report-of-refractory-mycobacterium-wolinskyi-knee-infection-in--peer-reviewed-fulltext-article-IDR; https://doaj.org/toc/1178-6973
Prístupová URL adresa: https://doaj.org/article/0258cd0e0e9d4d72b9a66568771feff6
Prístupové číslo: edsdoj.0258cd0e0e9d4d72b9a66568771feff6
Databáza: Directory of Open Access Journals
Popis
Abstrakt:Min Shao,1,* Lijia Ni,2,3,* Liang Jiang,4 Jingyi Hou,4 Sicheng Xu,4 Yin Lin,5 Xiaoying Xie6 1Department of Pharmacy, Liwan Central Hospital of Guangzhou, Guangzhou, 510000, People’s Republic of China; 2Department of Clinical Laboratory, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 3Institution of Antibiotic, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 4Department of Orthopedic Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 5Department of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 6Department of Clinical Laboratory, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518106, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoying Xie, Email xiexy5@mail.sysu.edu.cn Yin Lin, Email linyin@mail.sysu.edu.cnAbstract: Mycobacterium wolinskyi (M. wolinskyi), which is a rare rapidly growing mycobacterium (RGM), and the infections it causes are predominantly linked to surgery or invasive procedures. We detailed a case of refractory surgical site infection (SSI) caused by M. wolinskyi. The causative pathogen was identified by metagenomic next-generation sequencing (mNGS) analysis, 16S rRNA and rpoB gene sequencing. What renders this case particularly remarkable is the complexity introduced by a series of antibiotic-induced adverse effects, which seem to be deeply intertwined with the patient’s underlying metabolic syndrome. With the meticulous pharmaceutical guidance provided by the clinical pharmacist, the patient experienced a substantial improvement in his knee joint infection.Keywords: Mycobacterium wolinskyi, surgical site infection, metabolic syndrome, mNGS
ISSN:11786973