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Maternal exposure to arsenic in drinking water and risk of congenital heart disease in the offspring

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Názov: Maternal exposure to arsenic in drinking water and risk of congenital heart disease in the offspring
Autori: Richter, Frida, Kloster, Stine, Wodschow, Kirstine, Hansen, Birgitte, Schullehner, Jörg, Kristiansen, Søren Munch, Petersen, Mette Mains, Strandberg-Larsen, Katrine, Ersbøll, Annette Kjær
Zdroj: Richter, F, Kloster, S, Wodschow, K, Hansen, B, Schullehner, J, Kristiansen, S M, Petersen, M M, Strandberg-Larsen, K & Ersbøll, A K 2022, 'Maternal exposure to arsenic in drinking water and risk of congenital heart disease in the offspring', Environment International, vol. 160, 107051. https://doi.org/10.1016/j.envint.2021.107051
Rok vydania: 2022
Zbierka: University of Southern Denmark: Research Output / Syddansk Universitet
Predmety: Arsenic, Congenital heart disease, Drinking water, Maternal exposure, Population-based individual-level registers, Prenatal, Water Pollutants, Chemical/analysis, Maternal Exposure/statistics & numerical data, Heart Defects, Congenital/chemically induced, Humans, Infant, Male, Pregnancy, Drinking Water/chemistry, Environmental Exposure/analysis, Female, Arsenic/analysis, Child, Newborn, Cohort Studies
Popis: Introduction: Prenatal exposure to arsenic is suspected to impair fetal health, including congenital malformations. Few studies investigated an association between maternal exposure to arsenic and congenital heart disease. Objective: To examine the association between maternal exposure to arsenic through drinking water and congenital heart disease among offspring. Methods: This nationwide cohort study included all liveborn children in Denmark, 1997–2014. Maternal addresses at fetal age 4 weeks were linked to drinking water supply areas. Exposure was arsenic concentration in drinking water in first trimester in four categories (<0.5 μg/L, 0.5–0.9 μg/L, 1.0–4.9 μg/L, ≥5.0 μg/L). Outcomes were defined as congenital heart disease diagnosed within the first year of life, with sub-categorization of severe, septal defects and valvular heart defect. Associations between arsenic levels and congenital heart disease were analysed using logistic regression, presented as odds ratios (OR) with 95% confidence interval (CI), and adjusted for year of birth, mother's educational level and ethnicity. Results: A total of 1,042,413 liveborn children were included of whom 1.0% had a congenital heart disease. The OR of congenital heart disease was higher among children exposed to all levels of arsenic above 0.5 μg/L; the OR was 1.13 (95% CI: 1.08–1.19) for exposure of 0.5–0.9 μg/L, 1.33 (95% CI: 1.27–1.39) for 1.0–4.9 μg/L and 1.42 (95% CI: 1.24–1.63) for ≥5.0 μg/L. Similar associations were observed for congenital septal defects. The OR was also higher for severe congenital heart disease but at the same level among all exposure levels ≥0.5 μg/L. The OR of congenital valvular heart defects was only higher among children with maternal exposure to arsenic in drinking water ≥5.0 μg/L. The associations were similar for boys and girls. Conclusion: The findings indicate that maternal exposure to arsenic in drinking water even at low concentrations (i.e., 0.5–0.9 μg/L) increased the risk of congenital heart disease in the offspring.
Druh dokumentu: article in journal/newspaper
Popis súboru: application/pdf
Jazyk: English
DOI: 10.1016/j.envint.2021.107051
Dostupnosť: https://portal.findresearcher.sdu.dk/da/publications/b6743b01-0943-4004-8321-0fad55e6694d
https://doi.org/10.1016/j.envint.2021.107051
https://findresearcher.sdu.dk/ws/files/197563420/1_s2.0_S0160412021006760_main.pdf
Rights: info:eu-repo/semantics/openAccess
Prístupové číslo: edsbas.F96BD32C
Databáza: BASE
Popis
Abstrakt:Introduction: Prenatal exposure to arsenic is suspected to impair fetal health, including congenital malformations. Few studies investigated an association between maternal exposure to arsenic and congenital heart disease. Objective: To examine the association between maternal exposure to arsenic through drinking water and congenital heart disease among offspring. Methods: This nationwide cohort study included all liveborn children in Denmark, 1997–2014. Maternal addresses at fetal age 4 weeks were linked to drinking water supply areas. Exposure was arsenic concentration in drinking water in first trimester in four categories (<0.5 μg/L, 0.5–0.9 μg/L, 1.0–4.9 μg/L, ≥5.0 μg/L). Outcomes were defined as congenital heart disease diagnosed within the first year of life, with sub-categorization of severe, septal defects and valvular heart defect. Associations between arsenic levels and congenital heart disease were analysed using logistic regression, presented as odds ratios (OR) with 95% confidence interval (CI), and adjusted for year of birth, mother's educational level and ethnicity. Results: A total of 1,042,413 liveborn children were included of whom 1.0% had a congenital heart disease. The OR of congenital heart disease was higher among children exposed to all levels of arsenic above 0.5 μg/L; the OR was 1.13 (95% CI: 1.08–1.19) for exposure of 0.5–0.9 μg/L, 1.33 (95% CI: 1.27–1.39) for 1.0–4.9 μg/L and 1.42 (95% CI: 1.24–1.63) for ≥5.0 μg/L. Similar associations were observed for congenital septal defects. The OR was also higher for severe congenital heart disease but at the same level among all exposure levels ≥0.5 μg/L. The OR of congenital valvular heart defects was only higher among children with maternal exposure to arsenic in drinking water ≥5.0 μg/L. The associations were similar for boys and girls. Conclusion: The findings indicate that maternal exposure to arsenic in drinking water even at low concentrations (i.e., 0.5–0.9 μg/L) increased the risk of congenital heart disease in the offspring.
DOI:10.1016/j.envint.2021.107051