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Mental Disorders Among Offspring Prenatally Exposed to Systemic Glucocorticoids

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Název: Mental Disorders Among Offspring Prenatally Exposed to Systemic Glucocorticoids
Autoři: Laugesen, Kristina, Skajaa, Nils, Petersen, Irene, Skovsager Andersen, Marianne, Feldt-Rasmussen, Ulla, Kejlberg Al-Mashhadi, Sofie, Stewart, Paul, Jørgensen, Jens Otto Lunde, Sørensen, Henrik Toft
Zdroj: Laugesen , K , Skajaa , N , Petersen , I , Skovsager Andersen , M , Feldt-Rasmussen , U , Kejlberg Al-Mashhadi , S , Stewart , P , Jørgensen , J O L & Sørensen , H T 2025 , ' Mental Disorders Among Offspring Prenatally Exposed to Systemic Glucocorticoids ' , JAMA network open , vol. 8 , no. 1 , e2453245 . https://doi.org/10.1001/jamanetworkopen.2024.53245
Rok vydání: 2025
Sbírka: University of Copenhagen: Research / Forskning ved Københavns Universitet
Témata: Humans, Female, Pregnancy, Prenatal Exposure Delayed Effects/epidemiology, Glucocorticoids/adverse effects, Denmark/epidemiology, Male, Mental Disorders/epidemiology, Adolescent, Adult, Cohort Studies, Registries, Infant, Newborn, Autoimmune Diseases/epidemiology, Premature Birth/epidemiology
Popis: IMPORTANCE: Current evidence of the association between prenatal exposure to glucocorticoids and long-term mental disorders is scarce and has limitations. OBJECTIVE: To investigate the association between prenatal exposure to systemic glucocorticoids and mental disorders in offspring at the age of 15 years, comparing exposed vs unexposed offspring born to mothers with the same underlying disease (risk of preterm delivery and autoimmune or inflammatory disorders). DESIGN, SETTING, AND PARTICIPANTS: This nationwide population-based cohort study used data from registries in Denmark with follow-up until December 31, 2018. Participants included all Danish infants born alive from 1996 to 2016. Analyses were performed from January to December 2023. EXPOSURES: Prenatal exposure to systemic glucocorticoids. MAIN OUTCOMES AND MEASURES: Fifteen-year crude and adjusted risks, risk differences, and risk ratios (RR) for mental disorders using Kaplan-Meier estimator comparing exposed vs unexposed offspring born to mothers with the same underlying disease. RESULTS: A total of 1 061 548 infants (52% male) were included in the final study cohort, including 31 518 born to mothers at risk of preterm delivery and 288 747 born to mothers with autoimmune or inflammatory disorders. Among offspring born to mothers at risk of preterm delivery, the adjusted risks for exposed vs unexposed were 6.6% vs 4.3% (RR, 1.5 [95% CI, 1.2-1.9]) for autism spectrum disorders; 1.6% vs 1.3% (RR, 1.3 [95% CI, 0.8-1.8]) for intellectual disabilities; 5.8% vs 4.3% (RR, 1.3 [95% CI, 1.0-1.7]) for attention-deficit hyperactivity disorder (ADHD); and 7.2% vs 4.6% (RR, 1.5 [95% CI, 1.1-2.0]) for mood, anxiety, and stress-related disorders. Among offspring born to mothers with autoimmune or inflammatory disorders, the adjusted risks for exposed vs unexposed were 4.8% vs 3.8% (RR, 1.3 [95% CI, 1.1-1.5]) for autism spectrum disorders; 1.1% vs 0.8% (RR 1.4, [95% CI, 0.9-2.0]) for intellectual disabilities; 5.5% vs 4.4% (RR, 1.3 [95% CI, 1.0-1.5]) for ADHD; and ...
Druh dokumentu: article in journal/newspaper
Popis souboru: application/pdf
Jazyk: English
DOI: 10.1001/jamanetworkopen.2024.53245
Dostupnost: https://researchprofiles.ku.dk/da/publications/46c8bd43-4760-46a1-abc6-f323ebcba6dd
https://doi.org/10.1001/jamanetworkopen.2024.53245
https://curis.ku.dk/ws/files/419205249/laugesen_2025_oi_241484_1734643272.38515.pdf
Rights: info:eu-repo/semantics/openAccess
Přístupové číslo: edsbas.F7FE4DE7
Databáze: BASE
Popis
Abstrakt:IMPORTANCE: Current evidence of the association between prenatal exposure to glucocorticoids and long-term mental disorders is scarce and has limitations. OBJECTIVE: To investigate the association between prenatal exposure to systemic glucocorticoids and mental disorders in offspring at the age of 15 years, comparing exposed vs unexposed offspring born to mothers with the same underlying disease (risk of preterm delivery and autoimmune or inflammatory disorders). DESIGN, SETTING, AND PARTICIPANTS: This nationwide population-based cohort study used data from registries in Denmark with follow-up until December 31, 2018. Participants included all Danish infants born alive from 1996 to 2016. Analyses were performed from January to December 2023. EXPOSURES: Prenatal exposure to systemic glucocorticoids. MAIN OUTCOMES AND MEASURES: Fifteen-year crude and adjusted risks, risk differences, and risk ratios (RR) for mental disorders using Kaplan-Meier estimator comparing exposed vs unexposed offspring born to mothers with the same underlying disease. RESULTS: A total of 1 061 548 infants (52% male) were included in the final study cohort, including 31 518 born to mothers at risk of preterm delivery and 288 747 born to mothers with autoimmune or inflammatory disorders. Among offspring born to mothers at risk of preterm delivery, the adjusted risks for exposed vs unexposed were 6.6% vs 4.3% (RR, 1.5 [95% CI, 1.2-1.9]) for autism spectrum disorders; 1.6% vs 1.3% (RR, 1.3 [95% CI, 0.8-1.8]) for intellectual disabilities; 5.8% vs 4.3% (RR, 1.3 [95% CI, 1.0-1.7]) for attention-deficit hyperactivity disorder (ADHD); and 7.2% vs 4.6% (RR, 1.5 [95% CI, 1.1-2.0]) for mood, anxiety, and stress-related disorders. Among offspring born to mothers with autoimmune or inflammatory disorders, the adjusted risks for exposed vs unexposed were 4.8% vs 3.8% (RR, 1.3 [95% CI, 1.1-1.5]) for autism spectrum disorders; 1.1% vs 0.8% (RR 1.4, [95% CI, 0.9-2.0]) for intellectual disabilities; 5.5% vs 4.4% (RR, 1.3 [95% CI, 1.0-1.5]) for ADHD; and ...
DOI:10.1001/jamanetworkopen.2024.53245