Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics
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| Titel: | Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics |
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| Autoren: | Kan, Kwan Ting, Wilcock, Joel, Lu, Hui |
| Quelle: | Kan, K T, Wilcock, J & Lu, H 2024, 'Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics', Biochem Soc Trans, vol. 52, no. 3, pp. 1539–1548. https://doi.org/10.1042/BST20240450 |
| Publikationsjahr: | 2024 |
| Bestand: | The University of Manchester: Research Explorer - Publications |
| Schlagwörter: | i-AAA proteinase, mitochondrial protein homeostasis, mitochondrial protein import, oxidative phosphorylation complex, protein function, Mitochondrial Dynamics, ATPases Associated with Diverse Cellular Activities/metabolism, Proteostasis, Mitochondria/metabolism, Signal Transduction, Humans, Lipids/biosynthesis, Oxidative Phosphorylation, Homeostasis, Lipid Metabolism, Mitochondrial Proteins/metabolism, Protein Transport, Animals, ATP-Dependent Proteases/metabolism |
| Beschreibung: | Mitochondria are essential organelles of eukaryotic cells and thus mitochondrial proteome is under constant quality control and remodelling. Yme1 is a multi-functional protein and subunit of the homo-hexametric complex i-AAA proteinase. Yme1 plays vital roles in the regulation of mitochondrial protein homeostasis and mitochondrial plasticity, ranging from substrate degradation to the regulation of protein functions involved in mitochondrial protein biosynthesis, energy production, mitochondrial dynamics, and lipid biosynthesis and signalling. In this mini review, we focus on discussing the current understanding of the roles of Yme1 in mitochondrial protein import via TIM22 and TIM23 pathways, oxidative phosphorylation complex function, as well as mitochondrial lipid biosynthesis and signalling, as well as a brief discussion of the role of Yme1 in modulating mitochondrial dynamics. |
| Publikationsart: | article in journal/newspaper |
| Sprache: | English |
| DOI: | 10.1042/BST20240450 |
| Verfügbarkeit: | https://research.manchester.ac.uk/en/publications/cd7720dc-4d60-41ca-86c3-50f4af9ebf5a https://doi.org/10.1042/BST20240450 |
| Rights: | info:eu-repo/semantics/openAccess |
| Dokumentencode: | edsbas.F6419C3C |
| Datenbank: | BASE |
Nájsť tento článok vo Web of Science | Abstract: | Mitochondria are essential organelles of eukaryotic cells and thus mitochondrial proteome is under constant quality control and remodelling. Yme1 is a multi-functional protein and subunit of the homo-hexametric complex i-AAA proteinase. Yme1 plays vital roles in the regulation of mitochondrial protein homeostasis and mitochondrial plasticity, ranging from substrate degradation to the regulation of protein functions involved in mitochondrial protein biosynthesis, energy production, mitochondrial dynamics, and lipid biosynthesis and signalling. In this mini review, we focus on discussing the current understanding of the roles of Yme1 in mitochondrial protein import via TIM22 and TIM23 pathways, oxidative phosphorylation complex function, as well as mitochondrial lipid biosynthesis and signalling, as well as a brief discussion of the role of Yme1 in modulating mitochondrial dynamics. |
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| DOI: | 10.1042/BST20240450 |