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Longevity biotechnology:bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

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Title: Longevity biotechnology:bridging AI, biomarkers, geroscience and clinical applications for healthy longevity
Authors: Lyu, Yu-Xuan, Fu, Qiang, Wilczok, Dominika, Ying, Kejun, King, Aaron, Antebi, Adam, Vojta, Aleksandar, Stolzing, Alexandra, Moskalev, Alexey, Georgievskaya, Anastasia, Maier, Andrea B, Olsen, Andrea, Groth, Anja, Simon, Anna Katharina, Brunet, Anne, Jamil, Aisyah, Kulaga, Anton, Bhatti, Asif, Yaden, Benjamin, Pedersen, Bente Klarlund, Schumacher, Björn, Djordjevic, Boris, Kennedy, Brian, Chen, Chieh, Huang, Christine Yuan, Correll, Christoph U, Murphy, Coleen T, Ewald, Collin Y, Chen, Danica, Valenzano, Dario Riccardo, Sołdacki, Dariusz, Erritzoe, David, Meyer, David, Sinclair, David A, Chini, Eduardo Nunes, Teeling, Emma C, Morgen, Eric, Verdin, Eric, Vernet, Erik, Pinilla, Estefano, Fang, Evandro F, Bischof, Evelyne, Mercken, Evi M, Finger, Fabian, Kuipers, Folkert, Pun, Frank W, Gyülveszi, Gabor, Civiletto, Gabriele, Zmudze, Garri, Blander, Gil, Pincus, Harold A, McClure, Joshua, Kirkland, James L, Peyer, James, Justice, Jamie N, Vijg, Jan, Gruhn, Jennifer R, McLaughlin, Jerry, Mannick, Joan, Passos, João, Baur, Joseph A, Betts-LaCroix, Joe, Sedivy, John M, Speakman, John R, Shlain, Jordan, von Maltzahn, Julia, Andreasson, Katrin I, Moody, Kelsey, Palikaras, Konstantinos, Fortney, Kristen, Niedernhofer, Laura J, Rasmussen, Lene Juel, Veenhoff, Liesbeth M, Melton, Lisa, Ferrucci, Luigi, Quarta, Marco, Koval, Maria, Marinova, Maria, Hamalainen, Mark, Unfried, Maximilian, Ringel, Michael S, Filipovic, Milos, Topors, Mourad, Mitin, Natalia, Roy, Nawal, Pintar, Nika, Barzilai, Nir, Binetti, Paolo, Singh, Parminder, Kohlhaas, Paul, Robbins, Paul D, Rubin, Paul, Fedichev, Peter O, Kamya, Petrina, Muñoz-Canoves, Pura, de Cabo, Rafael, Faragher, Richard G A, Konrad, Rob, Ripa, Roberto, Mansukhani, Robin, Büttner, Sabrina, Wickström, Sara A, Brunemeier, Sebastian, Jakimov, Sergey, Luo, Shan, Rosenzweig-Lipson, Sharon, Tsai, Shih-Yin, Dimmeler, Stefanie, Rando, Thomas A, Peterson, Tim R, Woods, Tina, Wyss-Coray, Tony, Finkel, Toren, Strauss, Tzipora, Gladyshev, Vadim N, Longo, Valter D, Dwaraka, Varun B, Gorbunova, Vera, Acosta-Rodríguez, Victoria A, Sorrentino, Vincenzo, Sebastiano, Vittorio, Li, Wenbin, Suh, Yousin, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, Bakula, Daniela
Source: Lyu, Y-X, Fu, Q, Wilczok, D, Ying, K, King, A, Antebi, A, Vojta, A, Stolzing, A, Moskalev, A, Georgievskaya, A, Maier, A B, Olsen, A, Groth, A, Simon, A K, Brunet, A, Jamil, A, Kulaga, A, Bhatti, A, Yaden, B, Pedersen, B K, Schumacher, B, Djordjevic, B, Kennedy, B, Chen, C, Huang, C Y, Correll, C U, Murphy, C T, Ewald, C Y, Chen, D, Valenzano, D R, Sołdacki, D, Erritzoe, D, Meyer, D, Sinclair, D A, Chini, E N, Teeling, E C, Morgen, E, Verdin, E, Vernet, E, Pinilla, E, Fang, E F, Bischof, E, Mercken, E M, ....
Publication Year: 2024
Subject Terms: Humans, Aging/physiology, Artificial Intelligence, Biomarkers/metabolism, Biotechnology/methods, Geroscience/methods, Longevity/physiology
Description: The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.
Document Type: article in journal/newspaper
Language: English
DOI: 10.18632/aging.206135
Availability: https://research.vu.nl/en/publications/be232d5f-2c88-4f42-af2a-d173ea5cd579
https://doi.org/10.18632/aging.206135
https://hdl.handle.net/1871.1/be232d5f-2c88-4f42-af2a-d173ea5cd579
Rights: info:eu-repo/semantics/openAccess
Accession Number: edsbas.E9DAC2BD
Database: BASE
Description
Abstract:The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.
DOI:10.18632/aging.206135