ISSN:0974-276X JPB, an open access journal Volume 1(1): 006-010(2008)-006 Journal of Proteomics & Bioinformatics- Open Access www.omicsonline.com Research Article JPB/Vol.1/April 2008
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| Název: | ISSN:0974-276X JPB, an open access journal Volume 1(1): 006-010(2008)-006 Journal of Proteomics & Bioinformatics- Open Access www.omicsonline.com Research Article JPB/Vol.1/April 2008 |
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| Autoři: | J Proteomics Bioinform, Michael Kohl, Gorden Redlich, Martin Eisenacher, Anke Schnabel, Helmut E. Meyer, Katrin Marcus, Christian Stephan |
| Přispěvatelé: | The Pennsylvania State University CiteSeerX Archives |
| Zdroj: | http://omicsonline.com/Archive/April2008/JPB1.6.pdf. |
| Sbírka: | CiteSeerX |
| Témata: | Index, JDK, Java development kit, JVM, Java virtual machine |
| Popis: | Proteomics is a powerful methodology to investigate protein ex-pression in cells, tissues, organs or whole organisms. One funda-mental idea of proteomic approaches is the expression analysis of thousands of proteins at the same time. Proteome analysis more and more appears into the spotlight of classical fundamental as well as clinical research. Differential quantitative proteome analy-sis allows direct comparison of proteomes of different cellular states whereas descriptive qualitative approaches provide an in-sight in the protein composition of a given cell, organelle, tissue etc. Protein identification usually is done by mass spectrometry (MS). MS can be either performed in the form of whole-protein analysis (“top-down ” approach) or by investigation of enzymati-cally produced peptides (“bottom-up ” approach). In bottom-up proteomics approaches trypsin or other proteases are used to digest the proteins into a set of peptides prior to their |
| Druh dokumentu: | text |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.656.6869; http://omicsonline.com/Archive/April2008/JPB1.6.pdf |
| Dostupnost: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.656.6869 http://omicsonline.com/Archive/April2008/JPB1.6.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Přístupové číslo: | edsbas.E9B43C9D |
| Databáze: | BASE |
Nájsť tento článok vo Web of Science | Abstrakt: | Proteomics is a powerful methodology to investigate protein ex-pression in cells, tissues, organs or whole organisms. One funda-mental idea of proteomic approaches is the expression analysis of thousands of proteins at the same time. Proteome analysis more and more appears into the spotlight of classical fundamental as well as clinical research. Differential quantitative proteome analy-sis allows direct comparison of proteomes of different cellular states whereas descriptive qualitative approaches provide an in-sight in the protein composition of a given cell, organelle, tissue etc. Protein identification usually is done by mass spectrometry (MS). MS can be either performed in the form of whole-protein analysis (“top-down ” approach) or by investigation of enzymati-cally produced peptides (“bottom-up ” approach). In bottom-up proteomics approaches trypsin or other proteases are used to digest the proteins into a set of peptides prior to their |
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