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Hepatic arterial chemotherapy: role of angiography

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Názov: Hepatic arterial chemotherapy: role of angiography
Autori: Cho, K. J., Andrews, J. C., Williams, D. M., Doenz, F., Guy, G. E.
Rok vydania: 2025
Zbierka: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
Predmety: Antineoplastic Agents/*administration & dosage Catheterization/methods Hemodynamics *Hepatic Artery/radiography Humans Infusion Pumps *Infusions, Intra-Arterial/adverse effects/methods Liver Circulation Liver Neoplasms/blood supply/*drug therapy
Popis: Hepatic arterial infusion chemotherapy increases the hepatic concentration of chemotherapeutic agents without increasing systemic toxicity. Both percutaneous (most commonly left transbrachial) and surgical approaches are currently used for infusion catheter placement. Surgical catheter and pump placement has proved to be a reliable means of delivering drugs to the liver and has been commonly used for hepatic arterial chemotherapy for metastatic colorectal carcinoma. Meticulous angiographic evaluation of the hepatic vascular anatomy, its variations, and hemodynamics is necessary for correct catheter placement to achieve total liver perfusion without significant extrahepatic perfusion. Satisfactory hepatic perfusion should be documented before drug infusion. Hepatic arterial radionuclide flow imaging with technetium-99m-labeled macroaggregated serum albumin remains the most reliable means of assessing hepatic perfusion following catheter placement. Transcatheter techniques have been used to facilitate catheter placement, to prevent gastrointestinal drug toxicity, and to correct unsatisfactory perfusion following surgical catheter placement.
Druh dokumentu: article in journal/newspaper
Jazyk: unknown
ISSN: 0033-8419
Relation: Radiology; https://iris.unil.ch/handle/iris/117945; serval:BIB_5070B14BBC64; A1989CA08100042; 2813787
Dostupnosť: https://iris.unil.ch/handle/iris/117945
Prístupové číslo: edsbas.B846FD5D
Databáza: BASE
Popis
Abstrakt:Hepatic arterial infusion chemotherapy increases the hepatic concentration of chemotherapeutic agents without increasing systemic toxicity. Both percutaneous (most commonly left transbrachial) and surgical approaches are currently used for infusion catheter placement. Surgical catheter and pump placement has proved to be a reliable means of delivering drugs to the liver and has been commonly used for hepatic arterial chemotherapy for metastatic colorectal carcinoma. Meticulous angiographic evaluation of the hepatic vascular anatomy, its variations, and hemodynamics is necessary for correct catheter placement to achieve total liver perfusion without significant extrahepatic perfusion. Satisfactory hepatic perfusion should be documented before drug infusion. Hepatic arterial radionuclide flow imaging with technetium-99m-labeled macroaggregated serum albumin remains the most reliable means of assessing hepatic perfusion following catheter placement. Transcatheter techniques have been used to facilitate catheter placement, to prevent gastrointestinal drug toxicity, and to correct unsatisfactory perfusion following surgical catheter placement.
ISSN:00338419