Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019
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| Title: | Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019 |
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| Authors: | Hammerum, Anette M., Justesen, Ulrik S., Pinholt, Mette, Roer, Louise, Kaya, Hülya, Worning, Peder, Nygaard, Sanne, Kemp, Michael, Clausen, Marianne Engell, Nielsen, Karen Leth, Samulioniené, Jurgita, Kjærsgaard, Mona, Østergaard, Claus, Coia, John, Søndergaard, Turid Snekloth, Gaini, Shahin, Schønning, Kristian, Westh, Henrik, Hasman, Henrik, Holzknecht, Barbara Juliane |
| Source: | Hammerum, A M, Justesen, U S, Pinholt, M, Roer, L, Kaya, H, Worning, P, Nygaard, S, Kemp, M, Clausen, M E, Nielsen, K L, Samulioniené, J, Kjærsgaard, M, Østergaard, C, Coia, J, Søndergaard, T S, Gaini, S, Schønning, K, Westh, H, Hasman, H & Holzknecht, B J 2019, 'Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019', Eurosurveillance, vol. 24, no. 34, 1900503. https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503 |
| Publication Year: | 2019 |
| Collection: | University of Southern Denmark: Research Output / Syddansk Universitet |
| Subject Terms: | Enterococci, MLST, vanA, vanB, VRE, VVE, Prevalence, Humans, Multilocus Sequence Typing, Anti-Bacterial Agents/pharmacology, Electrophoresis, Gel, Pulsed-Field, Sequence Analysis, DNA, Gram-Positive Bacterial Infections/epidemiology, Enterococcus faecium/drug effects, Microbial Sensitivity Tests, Denmark/epidemiology, Bacterial Proteins/genetics, Polymerase Chain Reaction, Vancomycin/pharmacology, Carbon-Oxygen Ligases, Bacterial/genetics, Sentinel Surveillance, Vancomycin-Resistant Enterococci/drug effects |
| Description: | We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| DOI: | 10.2807/1560-7917.ES.2019.24.34.1900503 |
| Availability: | https://portal.findresearcher.sdu.dk/da/publications/02a6c38c-f2cf-4daf-b52b-5d038b5ecc6a https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503 https://findresearcher.sdu.dk/ws/files/153987494/Surveillance_of_vancomycin_resistant_enterococci_reveals_shift_in_dominating_clones_and_national_spread_of_a_vancomycin_variable_vanA_Enterococcus_faecium_ST1421_CT1134_clone_Denmark_2015_to_March_2019.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.B3ADE87A |
| Database: | BASE |
Nájsť tento článok vo Web of Science | Abstract: | We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone. |
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| DOI: | 10.2807/1560-7917.ES.2019.24.34.1900503 |