Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties
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| Název: | Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties |
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| Autoři: | M. Marinozzi, B. Natalini, G. Costantino, R. Pellicciari, BRUNO, Valeria Maria Gloria, NICOLETTI, Ferdinando |
| Přispěvatelé: | M., Marinozzi, B., Natalini, G., Costantino, R., Pellicciari, Bruno, Valeria Maria Gloria, Nicoletti, Ferdinando |
| Informace o vydavateli: | ELSEVIER SCIENCE SA |
| Rok vydání: | 1996 |
| Sbírka: | Sapienza Università di Roma: CINECA IRIS |
| Témata: | animal, cells cultured, cerebral cortex drug effect, female, mice, neuroprotective agents chemical synthesis/pharmacology, pregnancy, proline analogs /&/ derivatives/chemical synthesis/pharmacology, receptors glutamate drug effects |
| Popis: | 6,6-Dicarboxy-3,4-methano-L-proline (L-DCMP, 7) has been prepared by the rhodium(II)acetate dimer catalyzed decomposition of dimethyl diazomalonate in the presence of a 3,4-didehydroproline derivative. When evaluated against NMDA- and kainate-induced toxicity in cultured cortical neurons, L-DCMP (7) exhibited good neuroprotective activity. |
| Druh dokumentu: | article in journal/newspaper |
| Popis souboru: | STAMPA |
| Jazyk: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/8857207; info:eu-repo/semantics/altIdentifier/wos/WOS:A1996UB34800005; volume:51; issue:2; firstpage:121; lastpage:124; numberofpages:4; journal:IL FARMACO; http://hdl.handle.net/11573/461027; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1996UB34800005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a |
| Dostupnost: | http://hdl.handle.net/11573/461027 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1996UB34800005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a http://www.scopus.com/inward/record.url?eid=2-s2.0-0029932576&partnerID=65&md5=cf17198db94c6fa2ac77760abede1f2c |
| Přístupové číslo: | edsbas.9F3503FD |
| Databáze: | BASE |
Nájsť tento článok vo Web of Science | Abstrakt: | 6,6-Dicarboxy-3,4-methano-L-proline (L-DCMP, 7) has been prepared by the rhodium(II)acetate dimer catalyzed decomposition of dimethyl diazomalonate in the presence of a 3,4-didehydroproline derivative. When evaluated against NMDA- and kainate-induced toxicity in cultured cortical neurons, L-DCMP (7) exhibited good neuroprotective activity. |
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