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Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties

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Bibliographic Details
Title: Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties
Authors: M. Marinozzi, B. Natalini, G. Costantino, R. Pellicciari, BRUNO, Valeria Maria Gloria, NICOLETTI, Ferdinando
Contributors: M., Marinozzi, B., Natalini, G., Costantino, R., Pellicciari, Bruno, Valeria Maria Gloria, Nicoletti, Ferdinando
Publisher Information: ELSEVIER SCIENCE SA
Publication Year: 1996
Collection: Sapienza Università di Roma: CINECA IRIS
Subject Terms: animal, cells cultured, cerebral cortex drug effect, female, mice, neuroprotective agents chemical synthesis/pharmacology, pregnancy, proline analogs /&/ derivatives/chemical synthesis/pharmacology, receptors glutamate drug effects
Description: 6,6-Dicarboxy-3,4-methano-L-proline (L-DCMP, 7) has been prepared by the rhodium(II)acetate dimer catalyzed decomposition of dimethyl diazomalonate in the presence of a 3,4-didehydroproline derivative. When evaluated against NMDA- and kainate-induced toxicity in cultured cortical neurons, L-DCMP (7) exhibited good neuroprotective activity.
Document Type: article in journal/newspaper
File Description: STAMPA
Language: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/8857207; info:eu-repo/semantics/altIdentifier/wos/WOS:A1996UB34800005; volume:51; issue:2; firstpage:121; lastpage:124; numberofpages:4; journal:IL FARMACO; http://hdl.handle.net/11573/461027; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1996UB34800005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a
Availability: http://hdl.handle.net/11573/461027
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Accession Number: edsbas.9F3503FD
Database: BASE
Description
Abstract:6,6-Dicarboxy-3,4-methano-L-proline (L-DCMP, 7) has been prepared by the rhodium(II)acetate dimer catalyzed decomposition of dimethyl diazomalonate in the presence of a 3,4-didehydroproline derivative. When evaluated against NMDA- and kainate-induced toxicity in cultured cortical neurons, L-DCMP (7) exhibited good neuroprotective activity.