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Bidirectional 5-year risks of diabetic retinopathy, glaucoma and/or ocular hypertension:Results from a national screening programme

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Title: Bidirectional 5-year risks of diabetic retinopathy, glaucoma and/or ocular hypertension:Results from a national screening programme
Authors: Sperling, Signe, Stokholm, Lonny, Thykjaer, Anne Suhr, Pedersen, Frederik Nørregaard, Möller, Sören, Laugesen, Caroline Schmidt, Andersen, Nis, Andresen, Jens, Bek, Toke, la Cour, Morten, Hajari, Javad, Heegaard, Steffen, Højlund, Kurt, Kawasaki, Ryo, Kolko, Miriam, Schielke, Katja Christina, Rubin, Katrine Hass, Vestergaard, Anders Højslet, Grauslund, Jakob
Source: Sperling, S, Stokholm, L, Thykjaer, A S, Pedersen, F N, Möller, S, Laugesen, C S, Andersen, N, Andresen, J, Bek, T, la Cour, M, Hajari, J, Heegaard, S, Højlund, K, Kawasaki, R, Kolko, M, Schielke, K C, Rubin, K H, Vestergaard, A H & Grauslund, J 2023, 'Bidirectional 5-year risks of diabetic retinopathy, glaucoma and/or ocular hypertension : Results from a national screening programme', Acta Ophthalmologica, vol. 101, no. 4, pp. 384-391. https://doi.org/10.1111/aos.15300
Publication Year: 2023
Collection: University of Southern Denmark: Research Output / Syddansk Universitet
Subject Terms: diabetes, diabetic retinopathy, epidemiology, glaucoma, ocular hypertension, Prospective Studies, Cross-Sectional Studies, Humans, Risk Factors, Diabetes Mellitus, Ocular Hypertension/diagnosis, Diabetic Retinopathy/diagnosis, Glaucoma/diagnosis, Cohort Studies
Description: PURPOSE: We aimed to investigate if diabetic retinopathy (DR), glaucoma and/or ocular hypertension (OHT) are prospectively linked, as previous studies have proposed cross-sectional associations, but longitudinal data from larger cohorts are lacking. METHODS: We performed a bidirectional 5 years prospective, registry-based cohort study. We extracted data from national registers, including the Danish Registry of Diabetic Retinopathy, the Danish Civil Registration System, the Danish National Patient Register and the Danish National Prescription Registry. DR level was defined by the highest level of the two eyes. Glaucoma and/or OHT was defined by diagnostic codes (H40*) or at least three redeemed prescriptions of glaucoma medication (S01E*) within 1 year. We included 205 970 persons with diabetes and 1 003 170 age- and gender-matched non-diabetes controls. Exposures were level-specific DR (i) and glaucoma and/or OHT (ii), and outcomes were hazard ratios (HRs) for 5 years incident glaucoma and/or OHT (i) and DR (ii). RESULTS: Persons with diabetes were more likely to develop glaucoma and/or OHT (multivariable adjusted HR 1.11, 95% CI 1.06-1.15), but this did not depend on the level of DR. In persons with diabetes, those with glaucoma and/or OHT were more likely to develop DR (multivariable adjusted HR 1.12, 95% CI 1.03-1.23) within 5 years. CONCLUSION: In a national cohort, diabetes associated with a little higher risk of upcoming glaucoma and/or OHT, and, inversely, the presence of the latter predicted a higher risk of incident DR. Nevertheless, our data do not seem to justify including glaucoma evaluation in the national Danish DR-screening programme.
Document Type: article in journal/newspaper
File Description: application/pdf
Language: English
ISSN: 1755-375X
1755-3768
Relation: info:eu-repo/semantics/altIdentifier/pmid/36514165; info:eu-repo/semantics/altIdentifier/pissn/1755-375X; info:eu-repo/semantics/altIdentifier/eissn/1755-3768
DOI: 10.1111/aos.15300
Availability: https://portal.findresearcher.sdu.dk/da/publications/3e00e62a-660a-4fe4-ae73-a959a0688c0a
https://doi.org/10.1111/aos.15300
https://findresearcher.sdu.dk/ws/files/223124200/Acta_Ophthalmologica_2022_Sperling_Bidirectional_5_year_risks_of_diabetic_retinopathy_glaucoma_and_or_ocular.pdf
https://www.scopus.com/pages/publications/85144128949
Rights: info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc/4.0/
Accession Number: edsbas.98C02E17
Database: BASE
Description
Abstract:PURPOSE: We aimed to investigate if diabetic retinopathy (DR), glaucoma and/or ocular hypertension (OHT) are prospectively linked, as previous studies have proposed cross-sectional associations, but longitudinal data from larger cohorts are lacking. METHODS: We performed a bidirectional 5 years prospective, registry-based cohort study. We extracted data from national registers, including the Danish Registry of Diabetic Retinopathy, the Danish Civil Registration System, the Danish National Patient Register and the Danish National Prescription Registry. DR level was defined by the highest level of the two eyes. Glaucoma and/or OHT was defined by diagnostic codes (H40*) or at least three redeemed prescriptions of glaucoma medication (S01E*) within 1 year. We included 205 970 persons with diabetes and 1 003 170 age- and gender-matched non-diabetes controls. Exposures were level-specific DR (i) and glaucoma and/or OHT (ii), and outcomes were hazard ratios (HRs) for 5 years incident glaucoma and/or OHT (i) and DR (ii). RESULTS: Persons with diabetes were more likely to develop glaucoma and/or OHT (multivariable adjusted HR 1.11, 95% CI 1.06-1.15), but this did not depend on the level of DR. In persons with diabetes, those with glaucoma and/or OHT were more likely to develop DR (multivariable adjusted HR 1.12, 95% CI 1.03-1.23) within 5 years. CONCLUSION: In a national cohort, diabetes associated with a little higher risk of upcoming glaucoma and/or OHT, and, inversely, the presence of the latter predicted a higher risk of incident DR. Nevertheless, our data do not seem to justify including glaucoma evaluation in the national Danish DR-screening programme.
ISSN:1755375X
17553768
DOI:10.1111/aos.15300