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Síntese e caracterização de complexos de Cu(II), Ag(I) E Zn(II) com tripeptídeos: avaliação de atividade com xanthomonas citri subsp. citri ; Synthesis and characterization of Cu (II), Ag (I) AND Zn (II) complexes with tripeptide ligands: activity evaluation in xanthomonas citri subsp. citri

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Název: Síntese e caracterização de complexos de Cu(II), Ag(I) E Zn(II) com tripeptídeos: avaliação de atividade com xanthomonas citri subsp. citri ; Synthesis and characterization of Cu (II), Ag (I) AND Zn (II) complexes with tripeptide ligands: activity evaluation in xanthomonas citri subsp. citri
Autoři: Moraes, Carlos André Ferreira
Přispěvatelé: Silva, Maria Fátima das Graças Fernandes da, http://lattes.cnpq.br/0457632122660653, http://lattes.cnpq.br/2574358034018138
Informace o vydavateli: Universidade Federal de São Carlos
UFSCar
Programa de Pós-Graduação em Química - PPGQ
Câmpus São Carlos
Rok vydání: 2019
Sbírka: Repositório Institucional Universidade Federal de São Carlos (RI UFSCar)
Témata: Cancro cítrico, Peptídeos, Complexos metálicos, Citrus canker, Peptides, Metal complexes, CIENCIAS EXATAS E DA TERRA::QUIMICA, CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA ORGANICA::QUIMICA DOS PRODUTOS NATURAIS, CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA, CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA ORGANICA
Popis: SYNTHESIS AND CHARACTERIZATION OF Cu (II), Ag (I) AND Zn (II) COMPLEXES WITH TRIPEPTIDE LIGANDS: ACTIVITY EVALUATION IN XANTHOMONAS CITRI SUBSP. CITRI. In the search for new active substances against phytopathogens, were synthesized and characterized metal complexes with tripeptide L-Phenylalanine-Glycyl-Glycine (PGG), with general formula [Metal (PGG)]counterion, (PGG-1, PGG-2, PGG-3 and PGG-4), and the tripeptide Glycine-Glycyl-L-Histidine (GGH) of general formula [Metal (GGH)] (GGH-1, GGH-2, GGH-3 and GGH-4). These complexes were characterized by Elemental Analysis (C, H and N), Nuclear Magnetic Resonance (NMR) of 1H, 13C {1H}, one-dimensional and two-dimensional, high resolution mass spectrometry, absorption spectroscopy in ultraviolet-visible. The complexes PGG-1, PGG-2, PGG-3 and PGG-4, in water showed transitions n-π*, PGG-3 and PGG-4 exhibited d-d transitions. The GGH-1 and GGH-2 presented n-π* transitions, the complex GGH-3 and GGH-4 exhibited charge transfer bands (MLCT) and d-d transition. The differences found in the absorption spectrum bands in the infrared region (ligand and complex) were a smaller number of bands, inferring the rigidity caused by chelate formation. The copper (II) complexes were characterized by magnetic susceptibility, which are mononuclear. The complexes were tested on bacteria causing citrus canker, which had bacteriostatic activities, evaluated by technique serial microdilution, in which we obtained the Minimum Inhibitory Concentration (MIC), there was inhibited the growth of Xanthomonas citri subsp. citri, in lower concentration in some of the complexes (PGG-1, GGH-1 e PGG-3) compared to the salts used in the synthesis. The tripeptides used did not have bacteriostatic activity, related to the inhibition activity of bacterial growth to the synthesized complexes. ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; SÍNTESE E CARACTERIZAÇÃO DE COMPLEXOS DE COBRE (II), PRATA (I) E ZINCO (II) COM LIGANTES TRIPEPTÍDEOS: AVALIAÇÃO DE ATIVIDADE EM XANTHOMONAS CITRI ...
Druh dokumentu: thesis
Jazyk: Portuguese
Relation: MORAES, Carlos André Ferreira. Síntese e caracterização de complexos de Cu(II), Ag(I) E Zn(II) com tripeptídeos: avaliação de atividade com xanthomonas citri subsp. citri. 2019. Dissertação (Mestrado em Química) – Universidade Federal de São Carlos, São Carlos, 2019. Disponível em: https://repositorio.ufscar.br/handle/ufscar/12344.; https://repositorio.ufscar.br/handle/ufscar/12344
Dostupnost: https://repositorio.ufscar.br/handle/ufscar/12344
Rights: Attribution-NoDerivs 3.0 Brazil ; http://creativecommons.org/licenses/by-nd/3.0/br/
Přístupové číslo: edsbas.93E5E8F0
Databáze: BASE
Popis
Abstrakt:SYNTHESIS AND CHARACTERIZATION OF Cu (II), Ag (I) AND Zn (II) COMPLEXES WITH TRIPEPTIDE LIGANDS: ACTIVITY EVALUATION IN XANTHOMONAS CITRI SUBSP. CITRI. In the search for new active substances against phytopathogens, were synthesized and characterized metal complexes with tripeptide L-Phenylalanine-Glycyl-Glycine (PGG), with general formula [Metal (PGG)]counterion, (PGG-1, PGG-2, PGG-3 and PGG-4), and the tripeptide Glycine-Glycyl-L-Histidine (GGH) of general formula [Metal (GGH)] (GGH-1, GGH-2, GGH-3 and GGH-4). These complexes were characterized by Elemental Analysis (C, H and N), Nuclear Magnetic Resonance (NMR) of 1H, 13C {1H}, one-dimensional and two-dimensional, high resolution mass spectrometry, absorption spectroscopy in ultraviolet-visible. The complexes PGG-1, PGG-2, PGG-3 and PGG-4, in water showed transitions n-π*, PGG-3 and PGG-4 exhibited d-d transitions. The GGH-1 and GGH-2 presented n-π* transitions, the complex GGH-3 and GGH-4 exhibited charge transfer bands (MLCT) and d-d transition. The differences found in the absorption spectrum bands in the infrared region (ligand and complex) were a smaller number of bands, inferring the rigidity caused by chelate formation. The copper (II) complexes were characterized by magnetic susceptibility, which are mononuclear. The complexes were tested on bacteria causing citrus canker, which had bacteriostatic activities, evaluated by technique serial microdilution, in which we obtained the Minimum Inhibitory Concentration (MIC), there was inhibited the growth of Xanthomonas citri subsp. citri, in lower concentration in some of the complexes (PGG-1, GGH-1 e PGG-3) compared to the salts used in the synthesis. The tripeptides used did not have bacteriostatic activity, related to the inhibition activity of bacterial growth to the synthesized complexes. ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; SÍNTESE E CARACTERIZAÇÃO DE COMPLEXOS DE COBRE (II), PRATA (I) E ZINCO (II) COM LIGANTES TRIPEPTÍDEOS: AVALIAÇÃO DE ATIVIDADE EM XANTHOMONAS CITRI ...