Brain function in the vegetative state.
Uložené v:
| Názov: | Brain function in the vegetative state. |
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| Autori: | Laureys, Steven, Antoine, Sylvie, Boly, Mélanie, Elincx, Sandra, Faymonville, Marie-Elisabeth, Berré, Jacques, Sadzot, B., Ferring, Martine, De Tiege, Xavier, Van Bogaert, Patrick, Hansen, Isabelle, Damas, Pierre, Mavroudakis, Nicolas, Lambermont, Bernard, Del Fiore, Guy, Aerts, Joël, Degueldre, Christian, Phillips, Christophe, Franck, Georges, Vincent, Jean Louis, Lamy, Maurice, Luxen, André, Moonen, Gustave, Goldman, Serge, Maquet, Pierre |
| Zdroj: | Acta neurologica belgica, 102 (4 |
| Rok vydania: | 2002 |
| Zbierka: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| Predmety: | Sciences bio-médicales et agricoles, Cerebral Cortex -- pathology, Cerebral Cortex -- physiopathology, Cerebral Cortex -- radionuclide imaging, Cerebrovascular Circulation -- physiology, Consciousness -- physiology, Energy Metabolism -- physiology, Humans, Neural Pathways -- pathology, Neural Pathways -- physiopathology, Neural Pathways -- radionuclide imaging, Persistent Vegetative State -- pathology, Persistent Vegetative State -- physiopathology, Persistent Vegetative State -- radionuclide imaging, Recovery of Function -- physiology, Thalamus -- pathology, Thalamus -- physiopathology, Thalamus -- radionuclide imaging, Tomography, Emission-Computed, Brain metabolism cerebral blood flow, Brain plasticity, Consciousness, Functional connectivity, Functional neuroimaging, Positron emission tomography, Vegetative state |
| Popis: | Positron emission tomography (PET) techniques represent a useful tool to better understand the residual brain function in vegetative state patients. It has been shown that overall cerebral metabolic rates for glucose are massively reduced in this condition. However, the recovery of consciousness from vegetative state is not always associated with substantial changes in global metabolism. This finding led us to hypothesize that some vegetative patients are unconscious not just because of a global loss of neuronal function, but rather due to an altered activity in some critical brain regions and to the abolished functional connections between them. We used voxel-based Statistical Parametric Mapping (SPM) approaches to characterize the functional neuroanatomy of the vegetative state. The most dysfunctional brain regions were bilateral frontal and parieto-temporal associative cortices. Despite the metabolic impairment, external stimulation still induced a significant neuronal activation (i.e. change in blood flow) in vegetative patients as shown by both auditory click stimuli and noxious somatosensory stimuli. However, this activation was limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception. Finally, we demonstrated that vegetative patients have impaired functional connections between distant cortical areas and between the thalami and the cortex and, more importantly, that recovery of consciousness is paralleled by a restoration of this cortico-thalamo-cortical interaction. ; Journal Article ; Research Support, Non-U.S. Gov't ; Review ; info:eu-repo/semantics/published |
| Druh dokumentu: | article in journal/newspaper |
| Popis súboru: | 1 full-text file(s): application/pdf |
| Jazyk: | English |
| Relation: | uri/info:pmid/12534245; uri/info:scp/0036963136; https://dipot.ulb.ac.be/dspace/bitstream/2013/51284/3/Laureys_et_al.pdf |
| Dostupnosť: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51284 https://dipot.ulb.ac.be/dspace/bitstream/2013/51284/3/Laureys_et_al.pdf |
| Prístupové číslo: | edsbas.7ECE88BC |
| Databáza: | BASE |
Nájsť tento článok vo Web of Science | Abstrakt: | Positron emission tomography (PET) techniques represent a useful tool to better understand the residual brain function in vegetative state patients. It has been shown that overall cerebral metabolic rates for glucose are massively reduced in this condition. However, the recovery of consciousness from vegetative state is not always associated with substantial changes in global metabolism. This finding led us to hypothesize that some vegetative patients are unconscious not just because of a global loss of neuronal function, but rather due to an altered activity in some critical brain regions and to the abolished functional connections between them. We used voxel-based Statistical Parametric Mapping (SPM) approaches to characterize the functional neuroanatomy of the vegetative state. The most dysfunctional brain regions were bilateral frontal and parieto-temporal associative cortices. Despite the metabolic impairment, external stimulation still induced a significant neuronal activation (i.e. change in blood flow) in vegetative patients as shown by both auditory click stimuli and noxious somatosensory stimuli. However, this activation was limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception. Finally, we demonstrated that vegetative patients have impaired functional connections between distant cortical areas and between the thalami and the cortex and, more importantly, that recovery of consciousness is paralleled by a restoration of this cortico-thalamo-cortical interaction. ; Journal Article ; Research Support, Non-U.S. Gov't ; Review ; info:eu-repo/semantics/published |
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