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Life’s Simple 7 and Risk of Peripheral Artery Disease: Results from the PREDIMED Study and an Updated Meta-Analysis

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Název: Life’s Simple 7 and Risk of Peripheral Artery Disease: Results from the PREDIMED Study and an Updated Meta-Analysis
Autoři: López Laguna, Nieves, Toledo Atucha, Estefanía, Hershey, María S., Babio, Nancy, Sorlí, José V., Ros Rahola, Emilio, Muñoz Pérez, Miguel Ángel, Estruch Riba, Ramon, Lapetra, José, Muñoz Bravo, Carlos, Fiol Sala, Miguel, Bautista Castaño, Inmaculada, Pintó Sala, Xavier, Ortega Azorín, Carolina, Hernando Redondo, Javier, Salas Salvadó, Jordi, Tojal Sierra, Lucas, Martínez-González, Miguel Ángel, 1957-, Ruiz Canela, Miguel
Zdroj: Articles publicats en revistes (Medicina)
Informace o vydavateli: MDPI
Rok vydání: 2025
Sbírka: Dipòsit Digital de la Universitat de Barcelona
Témata: Malalties cardiovasculars, Assaigs clínics, Factors de risc en les malalties, Cuina mediterrània, Exercici terapèutic, Cardiovascular diseases, Clinical trials, Risk factors in diseases, Mediterranean cooking, Exercise therapy
Popis: Background: Peripheral artery disease (PAD) is a major vascular condition often overlooked in prevention strategies. We aimed to evaluate the association between cardiovascular health, measured by Life's Simple 7 (LS7), and the risk of PAD in a high-risk Mediterranean population. Methods: This prospective analysis included 7122 participants from the PREDIMED study (Prevención con Dieta Mediterránea) at high cardiovascular risk but free of cardiovascular disease at baseline. LS7 scores (0-14 points) were calculated using seven metrics: smoking status, body mass index, physical activity, blood pressure, total cholesterol, glucose metabolism, and adherence to the Mediterranean diet. Participants were categorized into inadequate (0-5), average (6-8), and optimal (9-14) cardiovascular health. Multivariable Cox regression models and Nelson-Aalen curves assessed the association between LS7 and PAD incidence over a median 4.8-year follow-up. A meta-analysis combining these results with three prior studies was also performed. Results: A total of 87 incident PAD cases were identified. Compared to participants with inadequate cardiovascular health, those with average and optimal LS7 scores exhibited significantly lower PAD risk (adjusted hazard ratio [HR] 0.37; 95% confidence interval [CI]: 0.22-0.61, and HR 0.25; 95% CI: 0.10-0.65, respectively). Each one-point increase in the LS7 score (range 0 to 14) was associated with an 22% lower PAD risk (HR 0.78; 95% CI: 0.68-0.90). The meta-analysis yielded a pooled HR of 0.81 (95% CI: 0.76-0.87), confirming consistent inverse associations across populations. Conclusions: Greater adherence to LS7 metrics is associated with a significantly reduced risk of PAD in high-risk Mediterranean individuals. Promoting LS7 adherence may represent an effective strategy for preventing both cardiovascular disease and PAD.
Druh dokumentu: article in journal/newspaper
Popis souboru: 13 p.; application/pdf
Jazyk: English
Relation: Reproducció del document publicat a: https://doi.org/10.3390/nu17132058; Nutrients, 2025, vol. 17, num.13; https://doi.org/10.3390/nu17132058; https://hdl.handle.net/2445/223048; 759726
Dostupnost: https://hdl.handle.net/2445/223048
Rights: cc-by (c) López-Laguna, N. et al., 2025 ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess
Přístupové číslo: edsbas.7A0517D1
Databáze: BASE
Popis
Abstrakt:Background: Peripheral artery disease (PAD) is a major vascular condition often overlooked in prevention strategies. We aimed to evaluate the association between cardiovascular health, measured by Life's Simple 7 (LS7), and the risk of PAD in a high-risk Mediterranean population. Methods: This prospective analysis included 7122 participants from the PREDIMED study (Prevención con Dieta Mediterránea) at high cardiovascular risk but free of cardiovascular disease at baseline. LS7 scores (0-14 points) were calculated using seven metrics: smoking status, body mass index, physical activity, blood pressure, total cholesterol, glucose metabolism, and adherence to the Mediterranean diet. Participants were categorized into inadequate (0-5), average (6-8), and optimal (9-14) cardiovascular health. Multivariable Cox regression models and Nelson-Aalen curves assessed the association between LS7 and PAD incidence over a median 4.8-year follow-up. A meta-analysis combining these results with three prior studies was also performed. Results: A total of 87 incident PAD cases were identified. Compared to participants with inadequate cardiovascular health, those with average and optimal LS7 scores exhibited significantly lower PAD risk (adjusted hazard ratio [HR] 0.37; 95% confidence interval [CI]: 0.22-0.61, and HR 0.25; 95% CI: 0.10-0.65, respectively). Each one-point increase in the LS7 score (range 0 to 14) was associated with an 22% lower PAD risk (HR 0.78; 95% CI: 0.68-0.90). The meta-analysis yielded a pooled HR of 0.81 (95% CI: 0.76-0.87), confirming consistent inverse associations across populations. Conclusions: Greater adherence to LS7 metrics is associated with a significantly reduced risk of PAD in high-risk Mediterranean individuals. Promoting LS7 adherence may represent an effective strategy for preventing both cardiovascular disease and PAD.