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Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording

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Bibliographic Details
Title: Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording
Authors: Gota Shinohara, Tasuku Kayama, Ayumu Okui, Wataru Oda, Atsushi Nishikawa, Alexander Loesing, Nahoko Kuga, Takuya Sasaki, Hiroto Sekiguchi
Source: Applied Physics Express, Vol 18, Iss 2, p 026501 (2025)
Publisher Information: IOP Publishing
Publication Year: 2025
Collection: Directory of Open Access Journals: DOAJ Articles
Subject Terms: microLED, GaN, optogenetics, neural probe, neural modulation, device process, Physics, QC1-999
Description: Optogenetics enables precise neural control but is limited by conventional optical fibers in complex networks. We present a hybrid device integrating multi-point micro-light-emitting diodes (MicroLEDs) with neural electrodes for localized light stimulation and simultaneous neural recording. Fabricated via direct bonding, it ensures optimal alignment for high spatial-temporal resolution. The thin MicroLED probes minimize invasiveness while maintaining optical performance. Validated in mouse brain models, the system achieves selective neural activation and recording with minimal thermal effects. This scalable, flexible tool overcomes integration challenges, advancing optogenetic research and opening avenues for exploring neural dynamics and targeted neurological therapies.
Document Type: article in journal/newspaper
Language: English
Relation: https://doi.org/10.35848/1882-0786/adaf0a; https://doaj.org/toc/1882-0786; https://doaj.org/article/ff714c50eea04dc8a69b256527758cbc
DOI: 10.35848/1882-0786/adaf0a
Availability: https://doi.org/10.35848/1882-0786/adaf0a
https://doaj.org/article/ff714c50eea04dc8a69b256527758cbc
Accession Number: edsbas.73C1F007
Database: BASE
Description
Abstract:Optogenetics enables precise neural control but is limited by conventional optical fibers in complex networks. We present a hybrid device integrating multi-point micro-light-emitting diodes (MicroLEDs) with neural electrodes for localized light stimulation and simultaneous neural recording. Fabricated via direct bonding, it ensures optimal alignment for high spatial-temporal resolution. The thin MicroLED probes minimize invasiveness while maintaining optical performance. Validated in mouse brain models, the system achieves selective neural activation and recording with minimal thermal effects. This scalable, flexible tool overcomes integration challenges, advancing optogenetic research and opening avenues for exploring neural dynamics and targeted neurological therapies.
DOI:10.35848/1882-0786/adaf0a