Analysis of infections in oncological patients with febrile neutropenia: integrative review ; Análise das infecções em pacientes oncológicos com neutropenia febril: revisão integrativa.
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| Názov: | Analysis of infections in oncological patients with febrile neutropenia: integrative review ; Análise das infecções em pacientes oncológicos com neutropenia febril: revisão integrativa. |
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| Autori: | Geraldo Dias, Giovanna, Ortega , José Roberto |
| Zdroj: | Brazilian Journal of Implantology and Health Sciences ; Vol. 7 No. 11 (2025): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807 - ÍNDICE H 19; 1673-1693 ; Vol. 7 Núm. 11 (2025): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807 - ÍNDICE H 19; 1673-1693 ; v. 7 n. 11 (2025): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807 - ÍNDICE H 19; 1673-1693 ; 2674-8169 |
| Informácie o vydavateľovi: | Editora Brazilian Scientific Publications |
| Rok vydania: | 2025 |
| Predmety: | COVID-19, Neutropenia Febril, Infecções Virais, Bacteremia, Agente antifúngico, oncologia, Febrile neutropenia, Bacterial infections, Fungal infections, Epidemiology, Infectology, Health problems, Oncologic Physiotherapy |
| Popis: | Febrile neutropenia (FN) is a frequent complication in patients undergoing chemotherapy, characterized by fever — defined as an oral temperature ≥ 38.3 °C or two consecutive measurements ≥ 38.0 °C at other body sites — combined with an absolute neutrophil count below 500 cells/mm³. This condition substantially increases the risk of severe infections and may compromise the continuity of antineoplastic treatment. This study aimed to describe the main infections in oncologic patients with febrile neutropenia, consolidating epidemiological and microbiological information. An integrative literature review was conducted, including articles published between 2013 and 2023, available in full text in PubMed, Scopus, Web of Science, ScienceDirect, and the Virtual Health Library. Studies presenting quantitative or qualitative data on the etiological profile of infections and related risk factors were selected. The analysis showed that bacterial infections represent the majority of FN episodes, with Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa being the most frequent Gram-negative bacilli, and Staphylococcus coagulase-negative and Streptococcus viridans the most common Gram-positive cocci. Fungal infections caused by Candida spp. and Aspergillus spp. were observed mainly in patients with prolonged neutropenia. Viral infections, though less prevalent, were also reported, including cytomegalovirus reactivation and viral hepatitis. It is concluded that the characterization of infections in patients with FN contributes to the epidemiological understanding of the condition, supports microbiological surveillance, and provides a basis for future research aimed at preventing infectious complications. ; A neutropenia febril (NF) é uma complicação frequente em pacientes submetidos a tratamento quimioterápico, caracterizada por febre, definida como temperatura oral ≥ 38,3 °C ou duas medidas consecutivas ≥ 38,0 °C em outro sítio corporal, associada à contagem de neutrófilos inferior a 500 células/mm³. Essa ... |
| Druh dokumentu: | article in journal/newspaper |
| Popis súboru: | application/pdf |
| Jazyk: | Portuguese |
| Relation: | https://bjihs.emnuvens.com.br/bjihs/article/view/6689/6511; https://bjihs.emnuvens.com.br/bjihs/article/view/6689 |
| DOI: | 10.36557/2674-8169.2025v7n11p1673-1693 |
| Dostupnosť: | https://bjihs.emnuvens.com.br/bjihs/article/view/6689 https://doi.org/10.36557/2674-8169.2025v7n11p1673-1693 |
| Rights: | Copyright (c) 2025 Giovanna Geraldo Dias, José Roberto Ortega ; https://creativecommons.org/licenses/by/4.0 |
| Prístupové číslo: | edsbas.5E2A460A |
| Databáza: | BASE |
Nájsť tento článok vo Web of Science | Abstrakt: | Febrile neutropenia (FN) is a frequent complication in patients undergoing chemotherapy, characterized by fever — defined as an oral temperature ≥ 38.3 °C or two consecutive measurements ≥ 38.0 °C at other body sites — combined with an absolute neutrophil count below 500 cells/mm³. This condition substantially increases the risk of severe infections and may compromise the continuity of antineoplastic treatment. This study aimed to describe the main infections in oncologic patients with febrile neutropenia, consolidating epidemiological and microbiological information. An integrative literature review was conducted, including articles published between 2013 and 2023, available in full text in PubMed, Scopus, Web of Science, ScienceDirect, and the Virtual Health Library. Studies presenting quantitative or qualitative data on the etiological profile of infections and related risk factors were selected. The analysis showed that bacterial infections represent the majority of FN episodes, with Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa being the most frequent Gram-negative bacilli, and Staphylococcus coagulase-negative and Streptococcus viridans the most common Gram-positive cocci. Fungal infections caused by Candida spp. and Aspergillus spp. were observed mainly in patients with prolonged neutropenia. Viral infections, though less prevalent, were also reported, including cytomegalovirus reactivation and viral hepatitis. It is concluded that the characterization of infections in patients with FN contributes to the epidemiological understanding of the condition, supports microbiological surveillance, and provides a basis for future research aimed at preventing infectious complications. ; A neutropenia febril (NF) é uma complicação frequente em pacientes submetidos a tratamento quimioterápico, caracterizada por febre, definida como temperatura oral ≥ 38,3 °C ou duas medidas consecutivas ≥ 38,0 °C em outro sítio corporal, associada à contagem de neutrófilos inferior a 500 células/mm³. Essa ... |
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| DOI: | 10.36557/2674-8169.2025v7n11p1673-1693 |