Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults
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| Titel: | Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults |
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| Weitere Verfasser: | Sun Young Shim, Ga Bin Lee, Jee-Seon Shim, Sun Jae Jung, Hyeon Chang Kim, Kim, Hyeon Chang |
| Verlagsinformationen: | EPIDEMIOLOGY AND HEALTH |
| Publikationsjahr: | 2021 |
| Schlagwörter: | Adult, Atherosclerosis / epidemiology, Carotid Artery Diseases / epidemiology, Cross-Sectional Studies, Diabetes Mellitus / epidemiology, Diabetes Mellitus / genetics, Family Health / statistics & numerical data, Female, Humans, Male, Middle Aged, Republic of Korea / epidemiology, Risk Assessment, Atherosclerosis, Carotid intima-media thickness, Diabetes mellitus, Medical history taking |
| Beschreibung: | Objectives: Diabetes is a well-known risk factor for atherosclerosis, but the association between a family history of diabetes and atherosclerosis remains unknown. In this study, we assessed the association between a family history of diabetes and increased carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in a middle-aged Korean population. Methods: This cross-sectional study included 3,974 community-dwelling adults (1,404 male and 2,570 female) aged 30-64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort. The presence of a family history of diabetes was assessed through face-to-face interviews using a standardized questionnaire. Carotid IMT was assessed using B-mode ultrasonography, and increased IMT was defined as a value in the top quartile of the IMT values of all participants. Multivariate logistic regression was used to evaluate independent associations between a family history of diabetes and increased IMT. Results: A family history of diabetes was significantly associated with increased carotid IMT (odds ratio, 1.23; 95% confidence interval, 1.03 to 1.48) after adjusting for sex; age; body mass index; systolic blood pressure; total cholesterol, triglyceride, and hemoglobin A1c levels; smoking; alcohol consumption; exercise; use of antidiabetic, antihypertensive, and antilipidemic drugs; and a family history of hypertension. The positive association remained significant after excluding participants with diabetes (odds ratio, 1.21; 95% confidence interval, 1.00 to 1.47). Conclusions: A family history of diabetes was positively associated with increased carotid IMT, even in participants without diabetes. Therefore, information on a family history of diabetes may help identify individuals at high risk of atherosclerotic cardiovascular disease. ; open |
| Publikationsart: | article in journal/newspaper |
| Dateibeschreibung: | application/pdf |
| Sprache: | unknown |
| ISSN: | 34525777 |
| Relation: | EPIDEMIOLOGY AND HEALTH; J00791; https://ir.ymlib.yonsei.ac.kr/handle/22282913/187408; T202124948; EPIDEMIOLOGY AND HEALTH, Vol.43 : e2021049, 2021 |
| DOI: | 10.4178/epih.e2021049 |
| Verfügbarkeit: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187408 https://doi.org/10.4178/epih.e2021049 |
| Rights: | CC BY-NC-ND 2.0 KR |
| Dokumentencode: | edsbas.5CE07EBE |
| Datenbank: | BASE |
Nájsť tento článok vo Web of Science | Abstract: | Objectives: Diabetes is a well-known risk factor for atherosclerosis, but the association between a family history of diabetes and atherosclerosis remains unknown. In this study, we assessed the association between a family history of diabetes and increased carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in a middle-aged Korean population. Methods: This cross-sectional study included 3,974 community-dwelling adults (1,404 male and 2,570 female) aged 30-64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort. The presence of a family history of diabetes was assessed through face-to-face interviews using a standardized questionnaire. Carotid IMT was assessed using B-mode ultrasonography, and increased IMT was defined as a value in the top quartile of the IMT values of all participants. Multivariate logistic regression was used to evaluate independent associations between a family history of diabetes and increased IMT. Results: A family history of diabetes was significantly associated with increased carotid IMT (odds ratio, 1.23; 95% confidence interval, 1.03 to 1.48) after adjusting for sex; age; body mass index; systolic blood pressure; total cholesterol, triglyceride, and hemoglobin A1c levels; smoking; alcohol consumption; exercise; use of antidiabetic, antihypertensive, and antilipidemic drugs; and a family history of hypertension. The positive association remained significant after excluding participants with diabetes (odds ratio, 1.21; 95% confidence interval, 1.00 to 1.47). Conclusions: A family history of diabetes was positively associated with increased carotid IMT, even in participants without diabetes. Therefore, information on a family history of diabetes may help identify individuals at high risk of atherosclerotic cardiovascular disease. ; open |
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| ISSN: | 34525777 |
| DOI: | 10.4178/epih.e2021049 |