Failure of vancomycin continuous infusion against experimental endocarditis due to vancomycin-intermediate Staphylococcus aureus.
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| Název: | Failure of vancomycin continuous infusion against experimental endocarditis due to vancomycin-intermediate Staphylococcus aureus. |
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| Autoři: | Entenza, J.M., Veloso, T.R., Vouillamoz, J., Giddey, M., Moreillon, P. |
| Rok vydání: | 2025 |
| Sbírka: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| Témata: | Animals, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents/therapeutic use, Endocarditis/drug therapy, Endocarditis/microbiology, Rats, Staphylococcus aureus/drug effects, Staphylococcus aureus/pathogenicity, Vancomycin/pharmacology, Vancomycin/therapeutic use, Vancomycin Resistance |
| Popis: | Continuous infusion of vancomycin was evaluated against experimental endocarditis due to heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and VISA. Animals were infected with hVISA PC1 (vancomycin MIC, 2 mg/liter) or VISA PC3 (vancomycin MIC, 8 mg/liter) and treated for 5 days with constant serum levels of 20 or 40 mg/liter. Vancomycin continuous infusion was unsuccessful, as 20 mg/liter was barely active against PC1 (6 of 13 sterile vegetations) and 40 mg/liter failed against PC3 (2 of 9 sterile vegetations). |
| Druh dokumentu: | article in journal/newspaper |
| Jazyk: | English |
| ISSN: | 1098-6596 |
| Relation: | Antimicrobial Agents and Chemotherapy; https://iris.unil.ch/handle/iris/88155; serval:BIB_13C7B4B119E1; 000285577400050 |
| DOI: | 10.1128/AAC.00811-10 |
| Dostupnost: | https://iris.unil.ch/handle/iris/88155 https://doi.org/10.1128/AAC.00811-10 |
| Přístupové číslo: | edsbas.5B150CF7 |
| Databáze: | BASE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Continuous infusion of vancomycin was evaluated against experimental endocarditis due to heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and VISA. Animals were infected with hVISA PC1 (vancomycin MIC, 2 mg/liter) or VISA PC3 (vancomycin MIC, 8 mg/liter) and treated for 5 days with constant serum levels of 20 or 40 mg/liter. Vancomycin continuous infusion was unsuccessful, as 20 mg/liter was barely active against PC1 (6 of 13 sterile vegetations) and 40 mg/liter failed against PC3 (2 of 9 sterile vegetations). |
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| ISSN: | 10986596 |
| DOI: | 10.1128/AAC.00811-10 |