Remote cognitive tests predict neurodegenerative biomarkers in the Insight 46 cohort
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| Titel: | Remote cognitive tests predict neurodegenerative biomarkers in the Insight 46 cohort |
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| Autoren: | Giovane, Martina Del, Giunchiglia, Valentina, Cai, Ziyuan, Leoni, Marguerite, Street, Rebecca, Lu, Kirsty, Wong, Andrew, Popham, Maria, Nicholas, Jennifer M, Trender, William, Hellyer, Peter J, Parker, Thomas D, Murray-Smith, Heidi, Cash, David M, Barnes, Josephine, Sudre, Carole H, Malhotra, Paresh A, Crutch, Sebastian J, Richards, Marcus, Hampshire, Adam, Schott, Jonathan M |
| Quelle: | Giovane, M D, Giunchiglia, V, Cai, Z, Leoni, M, Street, R, Lu, K, Wong, A, Popham, M, Nicholas, J M, Trender, W, Hellyer, P J, Parker, T D, Murray-Smith, H, Cash, D M, Barnes, J, Sudre, C H, Malhotra, P A, Crutch, S J, Richards, M, Hampshire, A & Schott, J M 2025, 'Remote cognitive tests predict neurodegenerative biomarkers in the Insight 46 cohort', Alzheimer's & Dementia, vol. 21, no. 2, e14572, pp. e14572. https://doi.org/10.1002/alz.14572 |
| Publikationsjahr: | 2025 |
| Bestand: | King's College, London: Research Portal |
| Schlagwörter: | Humans, Male, Female, Aged, Neuropsychological Tests/statistics & numerical data, Biomarkers, Alzheimer Disease/diagnosis, Brain/pathology, Cohort Studies, Magnetic Resonance Imaging, Cognition/physiology, Hippocampus/pathology, White Matter/pathology, Atrophy/pathology, Amyloid beta-Peptides |
| Beschreibung: | BACKGROUND: Alzheimer's disease-related biomarkers detect pathology years before symptoms emerge, when disease-modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early cognitive changes. We explored the relationship between neurodegenerative biomarkers and cognition in cognitively normal individuals. METHODS: We remotely deployed 13 computerized Cognitron tasks in 255 Insight 46 participants. We generated amyloid load and positivity, white matter hyperintensity volume (WMHV), whole brain and hippocampal volumes at age 73, plus rates of change over 2 years. We examined the relationship between Cognitron, biomarkers, and standard neuropsychological tests. RESULTS: Slower response time on a delayed recognition task predicted amyloid positivity (odds ratio [OR] = 1.79, confidence interval [CI]: 1.15, 2.95), and WMHV (1.23, CI: 1.00, 1.56). Brain and hippocampal atrophy rates correlated with poorer visuospatial performance (b = -0.42, CI: -0.80, -0.05) and accuracy on immediate recognition (b = -0.01, CI: -0.012, -0.001), respectively. Standard tests correlated with Cognitron composites (rho = 0.50, p < 0.001). DISCUSSION: Remote computerized testing correlates with standard supervised assessments and holds potential for studying early cognitive changes associated with neurodegeneration. HIGHLIGHTS: 70% of the Online 46 cohort performed a set of remote online cognitive tasks. Response time and accuracy on a memory task predicted amyloid status and load (SUVR). Accuracy on memory and spatial span tasks correlated with longitudinal atrophy rate. The Cognitron tasks correlated with standard supervised cognitive tests. Online cognitive testing can help identify early AD-related memory deficits. |
| Publikationsart: | article in journal/newspaper |
| Sprache: | English |
| DOI: | 10.1002/alz.14572 |
| Verfügbarkeit: | https://kclpure.kcl.ac.uk/portal/en/publications/6d428e69-9880-4ebc-93e6-a01b2a395c0d https://doi.org/10.1002/alz.14572 http://www.scopus.com/inward/record.url?scp=85218809726&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| Dokumentencode: | edsbas.5A445E34 |
| Datenbank: | BASE |
Nájsť tento článok vo Web of Science | Abstract: | BACKGROUND: Alzheimer's disease-related biomarkers detect pathology years before symptoms emerge, when disease-modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early cognitive changes. We explored the relationship between neurodegenerative biomarkers and cognition in cognitively normal individuals. METHODS: We remotely deployed 13 computerized Cognitron tasks in 255 Insight 46 participants. We generated amyloid load and positivity, white matter hyperintensity volume (WMHV), whole brain and hippocampal volumes at age 73, plus rates of change over 2 years. We examined the relationship between Cognitron, biomarkers, and standard neuropsychological tests. RESULTS: Slower response time on a delayed recognition task predicted amyloid positivity (odds ratio [OR] = 1.79, confidence interval [CI]: 1.15, 2.95), and WMHV (1.23, CI: 1.00, 1.56). Brain and hippocampal atrophy rates correlated with poorer visuospatial performance (b = -0.42, CI: -0.80, -0.05) and accuracy on immediate recognition (b = -0.01, CI: -0.012, -0.001), respectively. Standard tests correlated with Cognitron composites (rho = 0.50, p < 0.001). DISCUSSION: Remote computerized testing correlates with standard supervised assessments and holds potential for studying early cognitive changes associated with neurodegeneration. HIGHLIGHTS: 70% of the Online 46 cohort performed a set of remote online cognitive tasks. Response time and accuracy on a memory task predicted amyloid status and load (SUVR). Accuracy on memory and spatial span tasks correlated with longitudinal atrophy rate. The Cognitron tasks correlated with standard supervised cognitive tests. Online cognitive testing can help identify early AD-related memory deficits. |
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| DOI: | 10.1002/alz.14572 |