Pyrethroids and developmental neurotoxicity - A critical review of epidemiological studies and supporting mechanistic evidence
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| Title: | Pyrethroids and developmental neurotoxicity - A critical review of epidemiological studies and supporting mechanistic evidence |
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| Authors: | Andersen, Helle Raun, David, Arthur, Freire, Carmen, Fernández, Mariana F., D'Cruz, Shereen Cynthia, Reina-Pérez, Iris, Fini, Jean Baptiste, Blaha, Ludek |
| Source: | Andersen, H R, David, A, Freire, C, Fernández, M F, D'Cruz, S C, Reina-Pérez, I, Fini, J B & Blaha, L 2022, 'Pyrethroids and developmental neurotoxicity - A critical review of epidemiological studies and supporting mechanistic evidence', Environmental Research, vol. 214, no. Part 2, 113935. https://doi.org/10.1016/j.envres.2022.113935 |
| Publication Year: | 2022 |
| Collection: | University of Southern Denmark: Research Output / Syddansk Universitet |
| Subject Terms: | Adverse outcome pathways, Children, Insecticides, Neurodevelopment, Pyrethroids, Review, Epidemiologic Studies, Cross-Sectional Studies, Humans, Pyrethrins/metabolism, Pregnancy, Insecticides/toxicity, Thyroid Hormones, Female, Child |
| Description: | Background: Pyrethroid metabolites are widely detectable in urine from the general population, including pregnant women and children. Pyrethroids are neurotoxic and suggested endocrine disruptors. Exposure during vulnerable developmental time windows may have long-term impacts on neurodevelopment. Objective: To evaluate the epidemiological evidence for neurodevelopmental effects related to prenatal and childhood pyrethroid exposure in a systematic review and to assess biological plausibility by evaluating mechanistic evidence. Methods: We searched PubMed and Web of Science up to September 1, 2021 and included original studies published in English in which pyrethroid exposure was measured or estimated during pregnancy or childhood and associations with neurodevelopmental outcomes in the children were investigated. The Navigation Guide Systematic Review Methodology was used to evaluate the epidemiological evidence. For mechanistic evidence, we focused on relevant key events (KEs) suggested in Adverse Outcome Pathways (AOPs) using the OECD-supported AOP-wiki platform. A systematic search combining the KEs with pyrethroids, including 26 individual compounds, was performed in the ToxCast database. Results: Twenty-five epidemiological studies met the inclusion criteria, 17 presented findings on prenatal exposure, 10 on childhood exposure and two on both exposure windows. The overall body of evidence was rated as “moderate quality” with “sufficient evidence” for an association between prenatal pyrethroid exposure and adverse neurodevelopment. For childhood exposure, the overall rating was “low quality” with “limited evidence” because of cross-sectional study design. Regarding mechanistic evidence, we found that pyrethroids are able to interfere with neurodevelopmental KEs included in established AOPs for adverse neurodevelopmental. The evidence was strongest for interference with thyroid hormone (TH) function. Conclusion: Pyrethroids are probably human developmental neurotoxicants and adverse impacts of pyrethroid ... |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| DOI: | 10.1016/j.envres.2022.113935 |
| Availability: | https://portal.findresearcher.sdu.dk/da/publications/646fef41-b3dc-4a68-8a9e-d5edf5f9c047 https://doi.org/10.1016/j.envres.2022.113935 https://findresearcher.sdu.dk/ws/files/205392211/1_s2.0_S0013935122012622_main.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.5667D901 |
| Database: | BASE |
Nájsť tento článok vo Web of Science | Abstract: | Background: Pyrethroid metabolites are widely detectable in urine from the general population, including pregnant women and children. Pyrethroids are neurotoxic and suggested endocrine disruptors. Exposure during vulnerable developmental time windows may have long-term impacts on neurodevelopment. Objective: To evaluate the epidemiological evidence for neurodevelopmental effects related to prenatal and childhood pyrethroid exposure in a systematic review and to assess biological plausibility by evaluating mechanistic evidence. Methods: We searched PubMed and Web of Science up to September 1, 2021 and included original studies published in English in which pyrethroid exposure was measured or estimated during pregnancy or childhood and associations with neurodevelopmental outcomes in the children were investigated. The Navigation Guide Systematic Review Methodology was used to evaluate the epidemiological evidence. For mechanistic evidence, we focused on relevant key events (KEs) suggested in Adverse Outcome Pathways (AOPs) using the OECD-supported AOP-wiki platform. A systematic search combining the KEs with pyrethroids, including 26 individual compounds, was performed in the ToxCast database. Results: Twenty-five epidemiological studies met the inclusion criteria, 17 presented findings on prenatal exposure, 10 on childhood exposure and two on both exposure windows. The overall body of evidence was rated as “moderate quality” with “sufficient evidence” for an association between prenatal pyrethroid exposure and adverse neurodevelopment. For childhood exposure, the overall rating was “low quality” with “limited evidence” because of cross-sectional study design. Regarding mechanistic evidence, we found that pyrethroids are able to interfere with neurodevelopmental KEs included in established AOPs for adverse neurodevelopmental. The evidence was strongest for interference with thyroid hormone (TH) function. Conclusion: Pyrethroids are probably human developmental neurotoxicants and adverse impacts of pyrethroid ... |
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| DOI: | 10.1016/j.envres.2022.113935 |