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Associations between urinary biomarkers of oxidative stress and biomarkers of tobacco smoke exposure in smokers.

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Title: Associations between urinary biomarkers of oxidative stress and biomarkers of tobacco smoke exposure in smokers.
Authors: Sambiagio, N., Berthet, A., Wild, P., Sauvain, J.J., Auer, R., Schoeni, A., Rodondi, N., Feller, M., Humair, J.P., Berlin, I., Breider, F., Grandjean, D., Hopf, N.B.
Publication Year: 2025
Collection: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
Subject Terms: Adult, Female, Humans, Male, 8-Hydroxy-2'-Deoxyguanosine, Biomarkers/urine, Nicotine/analysis, Nitrosamines/urine, Oxidative Stress, Polycyclic Aromatic Hydrocarbons/analysis, Smokers, Tobacco Smoke Pollution/analysis, Volatile Organic Compounds/analysis, Air pollution, Biomonitoring, Oxidative stress biomarkers, Polycyclic aromatic hydrocarbons, Tobacco smoke exposure, Volatile organic compounds
Description: Oxidative stress can contribute to the development of diseases, and may originate from exposures to toxicants commonly found in air pollution and cigarette smoke such as polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs). Yet, associations between these exposures and oxidative stress biomarkers are poorly characterized. We report here novel associations between 14 exposure biomarkers of PAHs and VOCs, and two oxidative stress biomarkers; 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-isoprostaglandin F 2α (8-isoprostane) in urine obtained from smokers participating in an ongoing clinical study (ESTxENDS, NCT03589989). We also assessed associations between six biomarkers of tobacco smoke exposure (metabolites of nicotine and tobacco-specific nitrosamines (TSNAs)) and both oxidative stress biomarkers. We then quantified the relative importance of each family of the 20 exposure biomarkers on oxidative stress. Participating smokers (153 men and 117 women, median age 44 years) had on average smoked 25 [2-62] years and smoked about 17 [5-40] cigarettes per day at the time of the study. Multiple linear regression results showed an association between 8-oxodG concentrations and the following metabolites in decreasing relative importance: PAHs (beta coefficient β = 0.105, p-value <0.001, partial R 2 = 0.15) > VOCs (β = 0.028, p < 0.001, partial R 2 = 0.09) > nicotine (β = 0.226, p < 0.001, partial R 2 = 0.08); and between 8-isoprostane concentrations and metabolites of PAHs (β = 0.117, p < 0.001, partial R 2 = 0.14) > VOCs (β = 0.040, p < 0.001, partial R 2 = 0.14) > TSNAs (β = 0.202, p = 0.003, partial R 2 = 0.09) > nicotine (β = 0.266, p < 0.001, partial R 2 = 0.08). Behavioral factors known to contribute to oxidative stress, including sleep quality, physical activity, and alcohol consumption, did not play a significant role. Exposures to PAHs and VOCs among smokers were significantly associated with oxidative stress.
Document Type: article in journal/newspaper
File Description: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document
Language: English
ISSN: 1879-1026
Relation: Science of the Total Environment; https://iris.unil.ch/handle/iris/62673; serval:BIB_06ECED021475; 000863313200015
DOI: 10.1016/j.scitotenv.2022.158361
Availability: https://iris.unil.ch/handle/iris/62673
https://doi.org/10.1016/j.scitotenv.2022.158361
Accession Number: edsbas.558283C0
Database: BASE
Description
Abstract:Oxidative stress can contribute to the development of diseases, and may originate from exposures to toxicants commonly found in air pollution and cigarette smoke such as polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs). Yet, associations between these exposures and oxidative stress biomarkers are poorly characterized. We report here novel associations between 14 exposure biomarkers of PAHs and VOCs, and two oxidative stress biomarkers; 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-isoprostaglandin F 2α (8-isoprostane) in urine obtained from smokers participating in an ongoing clinical study (ESTxENDS, NCT03589989). We also assessed associations between six biomarkers of tobacco smoke exposure (metabolites of nicotine and tobacco-specific nitrosamines (TSNAs)) and both oxidative stress biomarkers. We then quantified the relative importance of each family of the 20 exposure biomarkers on oxidative stress. Participating smokers (153 men and 117 women, median age 44 years) had on average smoked 25 [2-62] years and smoked about 17 [5-40] cigarettes per day at the time of the study. Multiple linear regression results showed an association between 8-oxodG concentrations and the following metabolites in decreasing relative importance: PAHs (beta coefficient β = 0.105, p-value <0.001, partial R 2 = 0.15) > VOCs (β = 0.028, p < 0.001, partial R 2 = 0.09) > nicotine (β = 0.226, p < 0.001, partial R 2 = 0.08); and between 8-isoprostane concentrations and metabolites of PAHs (β = 0.117, p < 0.001, partial R 2 = 0.14) > VOCs (β = 0.040, p < 0.001, partial R 2 = 0.14) > TSNAs (β = 0.202, p = 0.003, partial R 2 = 0.09) > nicotine (β = 0.266, p < 0.001, partial R 2 = 0.08). Behavioral factors known to contribute to oxidative stress, including sleep quality, physical activity, and alcohol consumption, did not play a significant role. Exposures to PAHs and VOCs among smokers were significantly associated with oxidative stress.
ISSN:18791026
DOI:10.1016/j.scitotenv.2022.158361