Home-Time as a Surrogate Marker for Functional Outcome After Aneurysmal Subarachnoid Hemorrhage.
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| Titel: | Home-Time as a Surrogate Marker for Functional Outcome After Aneurysmal Subarachnoid Hemorrhage. |
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| Autoren: | Stienen, M.N., Smoll, N.R., Fung, C., Goldberg, J., Bervini, D., Maduri, R., Chiappini, A., Robert, T., May, A., Bijlenga, P., Zumofen, D., Roethlisberger, M., Seule, M.A., Marbacher, S., Fandino, J., Schatlo, B., Schaller, K., Keller, E., Bozinov, O., Regli, L. |
| Weitere Verfasser: | Swiss SOS Study Group, Burkhardt, J.K., Neidert, M.C., Maldaner, N., Finkenstädt, S., Schöni, D., Raabe, A., Beck, J., Mariani, L., Guzman, R., D'Alonzo, D., Daniel, R.T., Reinert, M., Ferrari, A., Hildebrandt, G., Weyerbrock, A., Corniola, M. |
| Publikationsjahr: | 2025 |
| Bestand: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| Schlagwörter: | Adult, Aged, Aneurysm, Ruptured/physiopathology, Female, Humans, Independent Living/statistics & numerical data, Intracranial Aneurysm/physiopathology, Linear Models, Male, Middle Aged, Outcome Assessment (Health Care), Patient Discharge, Residence Characteristics/statistics & numerical data, Subarachnoid Hemorrhage/physiopathology, Time Factors, cerebrovascular stroke, disability evaluation, intracranial aneurysm, intracranial hemorrhages, outcome measure, subarachnoid hemorrhage |
| Beschreibung: | Background and Purpose—Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH. Methods—We examined prospectively collected data from a nationwide multicenter registry of aSAH patients admitted to a tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). We calculated mean home-time (defined as days spent at home for the first 90 days after aSAH) and 95% CIs for each category of modified Rankin Scale at discharge and 1-year follow-up, using linear regression models to analyze home-time differences per modified Rankin Scale category. Results—We had home-time data from 1076 of 1866 patients (57.7%), and multiple imputation was used to fill-in missing data from the remaining 790 patients. Increasing home-time was associated with improved modified Rankin Scale scores at time of hospital discharge (P<0.0001) and at 1-year follow-up (P<0.0001). Within each of the 8 participating hospitals, the relationship between home-time and modified Rankin Scale was maintained. Conclusions—Home-time for the first 90 days after aSAH offers a robust and easily ascertainable outcome measure, discriminating particularly well across better recovery levels at time of hospital discharge and at 1-year follow-up. This measure complies with the modern trend of patient-centered healthcare and research, representing an outcome that is particularly relevant to the patient. |
| Publikationsart: | article in journal/newspaper |
| Sprache: | English |
| ISSN: | 1524-4628 |
| Relation: | Stroke; https://iris.unil.ch/handle/iris/66421; serval:BIB_2A4419A0B2A2; 000456427700056 |
| DOI: | 10.1161/STROKEAHA.118.022808 |
| Verfügbarkeit: | https://iris.unil.ch/handle/iris/66421 https://doi.org/10.1161/STROKEAHA.118.022808 |
| Dokumentencode: | edsbas.4A1D5590 |
| Datenbank: | BASE |
Nájsť tento článok vo Web of Science | Abstract: | Background and Purpose—Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH. Methods—We examined prospectively collected data from a nationwide multicenter registry of aSAH patients admitted to a tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). We calculated mean home-time (defined as days spent at home for the first 90 days after aSAH) and 95% CIs for each category of modified Rankin Scale at discharge and 1-year follow-up, using linear regression models to analyze home-time differences per modified Rankin Scale category. Results—We had home-time data from 1076 of 1866 patients (57.7%), and multiple imputation was used to fill-in missing data from the remaining 790 patients. Increasing home-time was associated with improved modified Rankin Scale scores at time of hospital discharge (P<0.0001) and at 1-year follow-up (P<0.0001). Within each of the 8 participating hospitals, the relationship between home-time and modified Rankin Scale was maintained. Conclusions—Home-time for the first 90 days after aSAH offers a robust and easily ascertainable outcome measure, discriminating particularly well across better recovery levels at time of hospital discharge and at 1-year follow-up. This measure complies with the modern trend of patient-centered healthcare and research, representing an outcome that is particularly relevant to the patient. |
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| ISSN: | 15244628 |
| DOI: | 10.1161/STROKEAHA.118.022808 |