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Performance in the Six-Minute Walking Test Does Not Discriminate Excessive Erythrocytosis Patients in a Severe Hypoxic Environment

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Název: Performance in the Six-Minute Walking Test Does Not Discriminate Excessive Erythrocytosis Patients in a Severe Hypoxic Environment
Autoři: Rojas-Chambilla, Rossela Alejandra, Vilca-Coaquira, Kely Melina, Tejada-Flores, Jeancarlo, Tintaya-Ramos, Henry Oscar, Quispe-Trujillo, Mariela Mercedes, Calisaya-Huacasi, Ángel Gabriel, Quispe-Humpiri, Solanyela Anny, Pino Vanegas, Yony Martin, Salazar-Granara, Alberto Alcibiades, Tácuna-Calderón, Ana Lucía, García-Bedoya, Nancy Mónica, Yang, Moua, Viscor Carrasco, Ginés, Hancco-Zirena, Iván
Zdroj: Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Informace o vydavateli: MDPI
Rok vydání: 2024
Sbírka: Dipòsit Digital de la Universitat de Barcelona
Témata: Andes, Anoxèmia, Influència de l'altitud, Hemoglobina, Anoxemia, Influence of altitude, Hemoglobin
Popis: Background: Chronic exposure to severe hypoxia causes an increase in hematocrit (Hct) and hemoglobin concentration ([Hb]), which can lead to excessive erythrocytosis (EE) and impact physical performance. This work aims to determine the differences in the six-minute walking test (6MWT) between EE and healthy subjects residing at more than 5000 m. Methods: A prospective, cross-sectional study was performed on 71 men (36 healthy and 25 suffering from EE) living in La Rinconada, Peru (5100 m). Basal levels of [Hb] and Hct were obtained. All the subjects performed the 6MWT, and distance reached, vital signs, dyspnea, and fatigue (Borg scale) at the end of the test were recorded. Results: The average [Hb] and Hct levels in the control group were 18.7 ± 1.2 g/dL and 60.4 ± 7.1%, respectively, contrasting with EE subjects, who showed 23.4 ± 1.6 g/dL and 73.6 ± 5.9% (p < 0.001). However, no statistically significant differences were observed in BMI or other anthropometric parameters. At the end of the 6MWT, the distance traveled and vital constants were similar between both groups, except for arterial oxygen saturation, which was consistently lower in subjects with EE throughout the test. Conclusion: EE does not significantly affect 6MWT performance at high altitudes, nor the hemodynamic control during moderate aerobic exercise of subjects who live permanently in a severely hypoxic environment.
Druh dokumentu: article in journal/newspaper
Popis souboru: 11 p.; application/pdf
Jazyk: English
Relation: Reproducció del document publicat a: https://doi.org/10.3390/ijerph21091119; International Journal of Environmental Research and Public Health, 2024, vol. 21, num.9, p. 1-11; https://doi.org/10.3390/ijerph21091119; https://hdl.handle.net/2445/215924; 750484
Dostupnost: https://hdl.handle.net/2445/215924
Rights: cc-by (c) Rojas-Chambilla, R.A. et al., 2024 ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess
Přístupové číslo: edsbas.48F3E2FF
Databáze: BASE
Popis
Abstrakt:Background: Chronic exposure to severe hypoxia causes an increase in hematocrit (Hct) and hemoglobin concentration ([Hb]), which can lead to excessive erythrocytosis (EE) and impact physical performance. This work aims to determine the differences in the six-minute walking test (6MWT) between EE and healthy subjects residing at more than 5000 m. Methods: A prospective, cross-sectional study was performed on 71 men (36 healthy and 25 suffering from EE) living in La Rinconada, Peru (5100 m). Basal levels of [Hb] and Hct were obtained. All the subjects performed the 6MWT, and distance reached, vital signs, dyspnea, and fatigue (Borg scale) at the end of the test were recorded. Results: The average [Hb] and Hct levels in the control group were 18.7 ± 1.2 g/dL and 60.4 ± 7.1%, respectively, contrasting with EE subjects, who showed 23.4 ± 1.6 g/dL and 73.6 ± 5.9% (p < 0.001). However, no statistically significant differences were observed in BMI or other anthropometric parameters. At the end of the 6MWT, the distance traveled and vital constants were similar between both groups, except for arterial oxygen saturation, which was consistently lower in subjects with EE throughout the test. Conclusion: EE does not significantly affect 6MWT performance at high altitudes, nor the hemodynamic control during moderate aerobic exercise of subjects who live permanently in a severely hypoxic environment.