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Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex

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Title: Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex
Authors: Filipchuk, Anton, Schwenkgrub, Joanna, Destexhe, Alain, Bathellier, Brice
Contributors: Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de l'Audition Paris (IDA), Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Funding was provided by the European Community, Future and Emerging Technologies program—Human Brain Project (no. H2020-945539 to A.D.), Paris-Saclay University ‘Initiatives de Recherches Stratégiques’—NeuroSaclay and Icode (to B.B. and A.D.), Agence Nationale pour la Recherche (no. 12-PDOC-0006 to B.B., PARADOX to A.D.), Région Ile de France—DIM Cerveau Pensée—MULTISENSE (to B.B.), Fondation pour l’Audition (nos. FPA IDA02 and APA 2016-03 to B.B.), and the European Research Council (no. CoG 770841 DEEPEN to B.B.). B.B. thanks the Fondation pour l’Audition for their support to the Institut de l’Audition., ANR-12-PDOC-0006,SENSEMAKER,Traitement cortical multisensoriel et émergence de percepts supra-modaux(2012), ANR-17-CE16-0024,PARADOX,Le sommeil paradoxical décodé(2017), European Project: 945539,H2020,H2020-SGA-FETFLAG-HBP-2019,HBP SGA3(2020)
Source: ISSN: 1097-6256.
Publisher Information: CCSD
Nature Publishing Group
Publication Year: 2022
Subject Terms: MESH: Acoustic Stimulation, MESH: Anesthetics, MESH: Animals, MESH: Auditory Cortex, MESH: Auditory Perception, MESH: Mice, MESH: Neurons, MESH: Perception, MESH: Wakefulness, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Description: International audience ; Neural activity in the sensory cortex combines stimulus responses and ongoing activity, but it remains unclear whether these reflect the same underlying dynamics or separate processes. In the present study, we show in mice that, during wakefulness, the neuronal assemblies evoked by sounds in the auditory cortex and thalamus are specific to the stimulus and distinct from the assemblies observed in ongoing activity. By contrast, under three different anesthetics, evoked assemblies are indistinguishable from ongoing assemblies in the cortex. However, they remain distinct in the thalamus. A strong remapping of sensory responses accompanies this dynamic state change produced by anesthesia. Together, these results show that the awake cortex engages dedicated neuronal assemblies in response to sensory inputs, which we suggest is a network correlate of sensory perception.
Document Type: article in journal/newspaper
Language: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/36171431; info:eu-repo/grantAgreement//945539/EU/Human Brain Project Specific Grant Agreement 3/HBP SGA3; PUBMED: 36171431; PUBMEDCENTRAL: PMC9534770
DOI: 10.1038/s41593-022-01168-5
Availability: https://hal.science/hal-03814483
https://hal.science/hal-03814483v2/document
https://hal.science/hal-03814483v2/file/s41593-022-01168-5.pdf
https://doi.org/10.1038/s41593-022-01168-5
Rights: http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
Accession Number: edsbas.452F7EFC
Database: BASE
Description
Abstract:International audience ; Neural activity in the sensory cortex combines stimulus responses and ongoing activity, but it remains unclear whether these reflect the same underlying dynamics or separate processes. In the present study, we show in mice that, during wakefulness, the neuronal assemblies evoked by sounds in the auditory cortex and thalamus are specific to the stimulus and distinct from the assemblies observed in ongoing activity. By contrast, under three different anesthetics, evoked assemblies are indistinguishable from ongoing assemblies in the cortex. However, they remain distinct in the thalamus. A strong remapping of sensory responses accompanies this dynamic state change produced by anesthesia. Together, these results show that the awake cortex engages dedicated neuronal assemblies in response to sensory inputs, which we suggest is a network correlate of sensory perception.
DOI:10.1038/s41593-022-01168-5