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Tau deposition is associated with functional isolation of the hippocampus in aging.

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Bibliographic Details
Title: Tau deposition is associated with functional isolation of the hippocampus in aging.
Authors: Harrison, Theresa M, Maaß, Anne, Adams, Jenna N, Du, Richard, Baker, Suzanne L, Jagust, William J
Source: Nature Communications 10(1), 4900 (2019). doi:10.1038/s41467-019-12921-z
Publisher Information: Nature Publishing Group UK
Publication Year: 2019
Subject Terms: info:eu-repo/classification/ddc/500, Adult, Aged, 80 and over, Aging: metabolism, Aging: physiology, Aging: psychology, Alzheimer Disease: diagnostic imaging, Alzheimer Disease: metabolism, Alzheimer Disease: physiopathology, Alzheimer Disease: psychology, Amyloid beta-Peptides: metabolism, Aniline Compounds, Brain: diagnostic imaging, Brain: metabolism, Brain: physiopathology, Carbolines, Cognitive Aging: physiology, Cognitive Aging: psychology, Contrast Media, Entorhinal Cortex: diagnostic imaging, Entorhinal Cortex: metabolism, Entorhinal Cortex: physiopathology, Executive Function, Female, Functional Neuroimaging, Hippocampus: diagnostic imaging, Hippocampus: metabolism, Hippocampus: physiopathology, Humans
Subject Geographic: DE
Description: The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we investigated tau-mediated mechanisms of hippocampal dysfunction that underlie the expression of episodic memory decline using fMRI measures of hippocampal local coherence (regional homogeneity; ReHo), distant functional connectivity and tau-PET. We show that age and tau pathology are related to higher hippocampal ReHo. Functional disconnection between the hippocampus and other components of the MTL memory system, particularly an anterior-temporal network specialized for object memory, is also associated with higher hippocampal ReHo and greater tau burden in anterior-temporal regions. These associations are not observed in the posteromedial network, specialized for context/spatial information. Higher hippocampal ReHo predicts worse memory performance. These findings suggest that tau pathology plays a role in disconnecting the hippocampus from specific MTL memory systems leading to increased local coherence and memory decline.
Document Type: article in journal/newspaper
Language: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:31653847; info:eu-repo/semantics/altIdentifier/issn/2041-1723; https://pub.dzne.de/record/141600
Availability: https://pub.dzne.de/record/141600
https://pub.dzne.de/search?p=id:%22DZNE-2020-07924%22
Rights: info:eu-repo/semantics/closedAccess
Accession Number: edsbas.4371B465
Database: BASE
Description
Abstract:The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we investigated tau-mediated mechanisms of hippocampal dysfunction that underlie the expression of episodic memory decline using fMRI measures of hippocampal local coherence (regional homogeneity; ReHo), distant functional connectivity and tau-PET. We show that age and tau pathology are related to higher hippocampal ReHo. Functional disconnection between the hippocampus and other components of the MTL memory system, particularly an anterior-temporal network specialized for object memory, is also associated with higher hippocampal ReHo and greater tau burden in anterior-temporal regions. These associations are not observed in the posteromedial network, specialized for context/spatial information. Higher hippocampal ReHo predicts worse memory performance. These findings suggest that tau pathology plays a role in disconnecting the hippocampus from specific MTL memory systems leading to increased local coherence and memory decline.