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fMRI reveals cognitive and emotional processing in a long-term comatose patient

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Bibliographic Details
Title: fMRI reveals cognitive and emotional processing in a long-term comatose patient
Authors: Eickhoff, S. B., Dafotakis, M., Grefkes, M., Stöcker, T., Shah, J. N., Schnitzler, A., Zilles, K., Siebler, M.
Source: Experimental neurology 214, 240 - 246 (2008). doi:10.1016/j.expneurol.2008.08.007
Publisher Information: Elsevier
Publication Year: 2008
Collection: Forschungszentrum Jülich: JuSER (Juelich Shared Electronic Resources)
Subject Terms: info:eu-repo/classification/ddc/610, Acoustic Stimulation, Adult, Amygdala: physiology, Cognition: physiology, Coma: physiopathology, Emotions: physiology, Female, Frontal Lobe: physiology, Humans, Magnetic Resonance Imaging, Persistent Vegetative State: physiopathology, Photic Stimulation, Physical Stimulation, Speech Perception: physiology, Temporal Lobe: physiology, Trauma, Language, Emotion, Persistent vegetative state, Minimally conscious state
Subject Geographic: DE
Description: We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited activation in Broca's and Wernicke's areas. Familiar speakers and direct addressing evoked significantly stronger amygdala activation than unfamiliar speakers and neutral phrases. This study hence demonstrates the potential of functional neuroimaging in the investigation of residual higher cortical functions in unresponsive comatose patients.
Document Type: article in journal/newspaper
Language: English
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000261483900010; info:eu-repo/semantics/altIdentifier/issn/0014-4886; info:eu-repo/semantics/altIdentifier/pmid/pmid:18789930
Availability: https://juser.fz-juelich.de/record/1852
https://juser.fz-juelich.de/search?p=id:%22PreJuSER-1852%22
Rights: info:eu-repo/semantics/closedAccess
Accession Number: edsbas.3EE95FB9
Database: BASE
Description
Abstract:We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited activation in Broca's and Wernicke's areas. Familiar speakers and direct addressing evoked significantly stronger amygdala activation than unfamiliar speakers and neutral phrases. This study hence demonstrates the potential of functional neuroimaging in the investigation of residual higher cortical functions in unresponsive comatose patients.