Building memories on prior knowledge: behavioral and fMRI evidence of impairment in early Alzheimer’s disease
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| Název: | Building memories on prior knowledge: behavioral and fMRI evidence of impairment in early Alzheimer’s disease |
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| Autoři: | Jonin, Pierre-Yves, Duché, Quentin, Bannier, Elise, Corouge, Isabelle, Ferré, Jean-Christophe, Belliard, Serge, Barillot, Christian, Barbeau, Emmanuel, J. |
| Přispěvatelé: | Centre de recherche cerveau et cognition (CERCO UMR5549), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Neuroimagerie: méthodes et applications (EMPENN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Inria de l'Université de Rennes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAL, IMAGE ET LANGAGE (IRISA-D6), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT), Service de Neurologie CHU Rennes, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou, Département de Radiologie CHU de Rennes, Université de Rennes (UR) |
| Zdroj: | ISSN: 0197-4580 ; Neurobiology of Aging ; https://hal.science/hal-03443296 ; Neurobiology of Aging, 2021, 110, pp.Pages 1-12. ⟨10.1016/j.neurobiolaging.2021.10.013.⟩. |
| Informace o vydavateli: | CCSD Elsevier |
| Rok vydání: | 2021 |
| Sbírka: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| Témata: | Alzheimer's disease, Perirhinal cortex, Prior knowledge, Recognition memory, Source memory, fMR, MESH: Age of Onset, MESH: Aged, MESH: Healthy Aging / psychology, MESH: Alzheimer Disease / diagnostic imaging, MESH: Alzheimer Disease / physiopathology, MESH: Alzheimer Disease / psychology, MESH: Association Learning / physiology, MESH: Behavior / physiology, MESH: Face / physiology, MESH: Female, MESH: Healthy Aging / physiology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SHS]Humanities and Social Sciences, [SHS.PSY]Humanities and Social Sciences/Psychology |
| Popis: | International audience ; Impaired memory is a hallmark of prodromal Alzheimer's disease (AD). Prior knowledge associated with the memoranda improves memory in healthy individuals, but we ignore whether the same occurs in early AD. We used functional MRI to investigate whether prior knowledge enhances memory encoding in early AD, and whether the nature of this prior knowledge matters. Patients with early AD and Controls underwent a task-based fMRI experiment where they learned face-scene associations. Famous faces carried pre-experimental knowledge (PEK), while unknown faces with which participants were familiarized prior to learning carried experimental knowledge (EK). Surprisingly, PEK strongly enhanced subsequent memory in healthy controls, but importantly not in patients. Partly nonoverlapping brain networks supported PEK vs. EK associative encoding in healthy controls. No such networks were identified in patients. In addition, patients displayed impaired activation in a right sub hippocampal region where activity predicted successful associative memory formation for PEK stimuli. Despite the limited sample sizes of this study, these findings suggest that the role prior knowledge in new learning might have been so far overlooked and underestimated in AD patients. Prior knowledge may drive critical differences in the way healthy elderly and early AD patients learn novel associations. |
| Druh dokumentu: | article in journal/newspaper |
| Jazyk: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34837869; PUBMED: 34837869 |
| DOI: | 10.1016/j.neurobiolaging.2021.10.013 |
| Dostupnost: | https://hal.science/hal-03443296 https://hal.science/hal-03443296v1/document https://hal.science/hal-03443296v1/file/Jonin_2020_revisedMS2-HAL.pdf https://doi.org/10.1016/j.neurobiolaging.2021.10.013 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| Přístupové číslo: | edsbas.3E584ECF |
| Databáze: | BASE |
Nájsť tento článok vo Web of Science | Abstrakt: | International audience ; Impaired memory is a hallmark of prodromal Alzheimer's disease (AD). Prior knowledge associated with the memoranda improves memory in healthy individuals, but we ignore whether the same occurs in early AD. We used functional MRI to investigate whether prior knowledge enhances memory encoding in early AD, and whether the nature of this prior knowledge matters. Patients with early AD and Controls underwent a task-based fMRI experiment where they learned face-scene associations. Famous faces carried pre-experimental knowledge (PEK), while unknown faces with which participants were familiarized prior to learning carried experimental knowledge (EK). Surprisingly, PEK strongly enhanced subsequent memory in healthy controls, but importantly not in patients. Partly nonoverlapping brain networks supported PEK vs. EK associative encoding in healthy controls. No such networks were identified in patients. In addition, patients displayed impaired activation in a right sub hippocampal region where activity predicted successful associative memory formation for PEK stimuli. Despite the limited sample sizes of this study, these findings suggest that the role prior knowledge in new learning might have been so far overlooked and underestimated in AD patients. Prior knowledge may drive critical differences in the way healthy elderly and early AD patients learn novel associations. |
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| DOI: | 10.1016/j.neurobiolaging.2021.10.013 |